产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
抗血管内皮生长因子抗体
目录 :
MBS175474
规格 :
0.1毫克
价格 :
245美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
目录号 :
MBS175474
产品类型 :
抗体
产品全称 :
抗血管内皮生长因子抗体
产品简称 :
血管内皮生长因子
产品名称同义词 :
血管内皮生长因子(血管内皮生长因子-A);血管内皮生长因子;MGC70609抗体;血管内皮生长因子抗体;血管内皮生长因子抗体;血管通透性因子抗体;血管内皮生长因子-A抗体;血管内皮生长因子A抗体;VEGFA_HUMAN抗体;VPF抗体
其他名称 :
血管内皮生长因子;血管内皮生长因子;血管内皮生长因子;血管通透性因子;血管内皮生长因子;血管通透性因子;VPF
产品基因名称 :
血管内皮生长因子A
其他基因名称 :
血管内皮生长因子A;血管内皮生长因子A;VPF;血管内皮生长因子;MVCD1;血管内皮生长因子;血管内皮生长因子-A;VPF
UniProt数据库进入名 :
VEGFA_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
232
特异性 :
No cross reactivity with other proteins.
纯度 :
免疫原亲和纯化
形式 :
冻干
储存稳定性 :
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化)石蜡
应用笔记 :
Western Blot:. Concentration: 0.1-0.5ug/ml. Test Species: Hu, Rat. Predicted Species: Ms . Antigen Retrieval: N/A. Immunohistochemistry (Paraffin-embedded Section):. Concentration: 0.5-1ug/ml. Test Species: Hu, Ms, Rat. Predicted Species: N/A . Antigen Retrieval: By Heat. Tested SPecies: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20 mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
其它信息1 :
Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human VEGF (33-48aa VDIFQEYPDEIEYIFK), identical to the related mouse and rat sequences.
其他信息2 :
Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
产品描述 :
Description: Rabbit IgG polyclonal antibody for Vascular endothelial growth factor A(VEGFA) detection. Tested with WB, IHC-P in Human, Mouse, Rat. Background: VEGF, a homodimeric glycoprotein of relative molecular mass 45,000, is the only mitogen that specifically acts on endothelial cells. It may be a major regulator of tumor angiogenesis in vivo. Vascular endothelial growth factor is a mitogen primarily for vascular endothelial cells. It is, however, structurally related to platelet-derived growth factor. VEGF shares homology with the PDGF A chain and B chain, including conservation of all 8 cysteines found in PDGFA and PDGFB. VEGF gene contains 8 exons. Vascular endothelial growth factor(VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Vascular endothelial growth factor(VEGF) stimulates neurogenesis in vitro and in vivo.
NCBI GI登录号 :
17380528
NCBI登录号 :
P15692.2
UniProt数据库登录号 :
P15692
NCBI分子量 :
34,406 Da
NCBI信号通路 :
Angiogenesis Pathway (198772); Axon Guidance Pathway (105688); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); Cellular Response To Hypoxia Pathway (645259); Cellular Responses To Stress Pathway (645258); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Developmental Biology Pathway (477129); EPH-Ephrin Signaling Pathway (1016174)
NCBI总结 :
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008]
尺寸1 :
0.1毫克
价格1 :
245美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。