抗体

抗EDA抗体

MBS175494

0.1毫克

245美元

多克隆

兔

未共轭

抗体

抗EDA抗体

EDA

Ectodysplasin-A; ectodysplasin A; Ectodermal dysplasia 1, anhidrotic antibody; Ectodermal dysplasia protein antibody; Ectodermal dysplasia, anhidrotic(hypohydrotic) antibody; Ectodysplasin A antibody; Ectodysplasin A, membrane form antibody; Ectodysplasin A, secreted form antibody; ECTODYSPLASIN A1 ISOFORM antibody; ECTODYSPLASIN A2 ISOFORM antibody; ECTODYSPLASIN antibody; Ectodysplasin-A antibody; ED1 A1 antibody; ED1 A2 antibody; ED1 antibody; ED1 GENE antibody; Eda A1 antibody; Eda A2 antibody; eda antibody; EDA protein antibody; EDA protein homolog antibody; EDA_HUMAN antibody; EDA1 antibody; EDA1 GENE antibody; EDA2 antibody; HED antibody; ODT1 antibody; Oligodontia 1 antibody; secreted form antibody; STHAGX1 antibody; Ta antibody; Tabby antibody; Tabby protein antibody; X linked anhidroitic ectodermal dysplasia protein antibody; XHED antibody; XLHED antibody

Ectodysplasin-A; Ectodysplasin-A; ectodysplasin-A; oligodontia 1; X-linked anhidroitic ectodermal dysplasia protein; ectodysplasin A; Ectodermal dysplasia protein; EDA protein

EDA

EDA;EDA;ED1;HED;EDA1;EDA2;HED1;ODT1;XHED;ECTD1;XLHED;ED1-A1;ED1-A2;EDA-A1;EDA-A2;STHAGX1;ED1;EDA2;EDA蛋白

EDA_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

391

免疫原亲和纯化

冻干

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

免疫印迹(免疫印迹)

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human EDA (254-269aa HLQGQGSAIQVKNDLS), identical to the related mouse and rat sequences.

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for Ectodysplasin-A(EDA) detection. Tested with WB in Human, Mouse, Rat. Background: Anhidrotic ectodermal dysplasia(EDA) is an X-linked recessive disorder which affects ectodermal structures. Ectodysplasin-A, the protein encoded by the EDA gene, is a member of the tumor necrosis factor ligand superfamily that forms a collagen triple helix, suggesting functions in signal transduction and cell adhesion. Wnt signaling does control EDA gene expression, but ectodysplasin-A does not feedback on the Wnt pathway.

6166135

Q92838.2

Q92838

40,750 Da

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460)

The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

EDA: Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR. Defects in EDA are the cause of ectodermal dysplasia type 1 (ED1); also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias. Defects in EDA are the cause of tooth agenesis selective X-linked type 1 (STHAGX1). A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). Belongs to the tumor necrosis factor family. 8 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: Xq12-q13.1. Cellular Component: endoplasmic reticulum membrane; collagen; cytoskeleton; membrane; intracellular membrane-bound organelle; apical part of cell; integral to plasma membrane; integral to membrane; plasma membrane; extracellular region. Molecular Function: protein binding; tumor necrosis factor receptor binding; receptor binding. Biological Process: pigmentation; cell-matrix adhesion; ectoderm development; immune response; positive regulation of NF-kappaB import into nucleus; gene expression; cell differentiation; signal transduction; activation of NF-kappaB transcription factor; odontogenesis of dentine-containing teeth. Disease: Tooth Agenesis, Selective, X-linked, 1; Ectodermal Dysplasia 1, Hypohidrotic, X-linked

0.1毫克

245美元