抗体

抗核纤层蛋白B1抗体

MBS175517

0.1毫克

245美元

多克隆

兔

未共轭

人类, 大鼠

免疫印迹, 免疫组化, 免疫组化-石蜡切片

抗体

抗核纤层蛋白B1抗体

核纤层蛋白B1

核纤层蛋白B1;核纤层蛋白B1;ADLD抗体;核纤层蛋白B1抗体;核纤层蛋白B1抗体;LMN抗体;LMN2抗体;LMNB抗体;Lmnb1抗体;LMNB1_HUMAN抗体;MGC111419抗体;OTTHUMP00000159218抗体

核纤层蛋白B1;核纤层蛋白B1;核纤层蛋白B1;核纤层蛋白B1

LMNB1

LMNB1;LMNB1;LMN;ADLD;LMN2;LMNB;LMN2;LMNB

LMNB1_HUMAN

多克隆

IgG

兔

人类, 大鼠

586

免疫原亲和纯化

冻干

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

免疫印迹(免疫印迹), 免疫组化(免疫组化)石蜡, 免疫组化(免疫组化)福尔马林, 免疫细胞化学免疫细胞化学

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Lamin B1 (570-586aa FHQQGTPRASNRSCAIM), different from the related rat sequence by one amino acid, and from the related mouse sequence by three amino acids.

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for Lamin-B1(LMNB1) detection. Tested with WB, IHC-P, IHC-F, ICC in Human, Rat. Background: Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are though to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.

125953

P20700.2

P20700

66,408 Da

Apoptosis Pathway (105648); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); Breakdown Of The Nuclear Lamina Pathway (105681); Caspase Cascade In Apoptosis Pathway (137974); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Cellular Senescence Pathway (905991); Cellular Responses To Stress Pathway (645258); DNA Damage/Telomere Stress Induced Senescence Pathway (905994)

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]

Lamin B1: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 5q23.2. Cellular Component: nucleoplasm; nuclear membrane; membrane; lamin filament; nuclear inner membrane; nuclear envelope. Molecular Function: phospholipase binding; structural molecule activity. Biological Process: apoptosis; cell structure disassembly during apoptosis. Disease: Leukodystrophy, Demyelinating, Adult-onset, Autosomal Dominant

0.1毫克

245美元