抗体

抗血管生成素2抗体

MBS177699

0.1毫克

315美元

多克隆

unidentified

未共轭

人类, 小鼠, 大鼠

免疫组化, 免疫组化-石蜡切片

抗体

抗血管生成素2抗体

[血管生成素2]

[血管生成素2;AGPT 2;Agpt2;ANG 2;ANG-2;ANG2;ANG2;血管生成素2a;血管生成素2B;血管生成素2;Angiopoietin2;ANGP2_HUMAN;ANGPT 2;ANGPT2;ANGPT2;Tie2配体;血管生成素2]

[angiopoietin-2 isoform b; Angiopoietin-2; angiopoietin-2; angiopoietin 2]

[ANGPT2;ANGPT2;ANG2;AGPT2;ANG-2]

ANGP2_HUMAN

多克隆

未知

人类, 小鼠, 大鼠

495

免疫原亲和纯化

Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

免疫组化(免疫组化)石蜡

Immunohistochemistry: . Concentration: 0.5-1 ug/ml. Tested Species: Hu, Ms, Rat. Antigen Retrieval: By Heat. Tested Species: In house tested species with positive results. By Heat: Boiling paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections. <br.Other applicatins have not been tested. Optimal dilutions should be determined by end users.

免疫组化(免疫组化)

免疫组化(免疫组化)

免疫组化(免疫组化)

Immunogen: E Coli-derived human Angiopoietin 2 recombinant protein (Position: Y19-N348). Human Angiopoietin 2 shares 84% and 85% amino acid (aa) sequences identity with mouse and rat Angiopoietin 2, respectively. Ig Type: Rabbit IgG

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Description: Rabbit IgG polyclonal antibody for Angiopoietin-2(ANGPT2) detection. Tested with IHC-P in Human;Mouse;Rat. Background: ANGPT2, also known as ANG2 or Angiopoietin 2, is a protein that in humans is encoded by the ANGPT2 gene. It is mapped to 8p23.1. ANGPT2 is a naturally occurring antagonist of ANG1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation during vasculogenesis. The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. ANGPT2 was significantly increased in plasma and alveolar edema fluid in adults with acute lung injury compared to controls or patients with hydrostatic pulmonary edema, tracheal. ANGPT2 was also significantly increased in neonates with respiratory distress syndrome who developed bronchopulmonary edema. It is also a mediator of epithelial necrosis with an important role in hyperoxic acute lung injury and pulmonary edema.

1. Bhandari, V., Choo-Wing, R., Lee, C. G., Zhu, Z., Nedrelow, J. H., Chupp, G. L., Zhang, X., Matthay, M. A., Ware, L. B., Homer, R. J., Lee, P. J., Geick, A., de Fougerolles, A. R., Elias, J. A. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nature Med. 12: 1286-1293, 2006. 2. Kim, I., Kim, J.-H., Ryu, Y. S., Jung, S. H., Nah, J. J., Koh, G. Y. Characterization and expression of a novel alternatively spliced human angiopoietin-2. J. Biol. Chem. 275: 18550-18556, 2000. 3. Cheung AH, Stewart RJ, Marsden PA (Jun 1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23". Genomics 48 (3): 389-91. 4. Fiedler, Ulrike; Krissl Tanja, Koidl Stefanie, Weiss Cornelia, Koblizek Thomas, Deutsch Urban, Martiny-Baron Georg, Marmé Dieter, Augustin Hellmut G (Jan 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". J. Biol. Chem. (United States) 278 (3): 1721-7.

169646749

NP_001112359.1

NM_001118887.1

O15123

56,848 Da

Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Cell Surface Interactions At The Vascular Wall Pathway (1269373); HIF-1 Signaling Pathway (695200); Hemostasis Pathway (1269340); PI3K-Akt Signaling Pathway (692234); PI3K-Akt Signaling Pathway (692979); Rap1 Signaling Pathway (868086); Rap1 Signaling Pathway (878042); Ras Signaling Pathway (868085); Tie2 Signaling Pathway (1269374)

The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ANGPT2: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 8p23.1. Cellular Component: cell projection; extracellular region; extracellular space; nucleus; plasma membrane. Molecular Function: metal ion binding; protein binding; receptor binding; receptor tyrosine kinase binding. Biological Process: angiogenesis; germ cell development; leukocyte migration; maternal process involved in pregnancy; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of positive chemotaxis; organ regeneration; positive regulation of angiogenesis; response to activity; response to glucose stimulus; response to hypoxia; response to mechanical stimulus; response to organic cyclic substance; response to radiation; signal transduction; Tie receptor signaling pathway

0.1毫克

315美元