产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
抗TGM2抗体
目录 :
MBS177799
规格 :
0.1毫克
价格 :
315美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫组化-石蜡切片
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS177799 图像 1
Anti- TGM2 Picoband antibody, MBS177799, Western blotting. All lanes: Anti TGM2 (MBS177799) at 0.5ug/ml. Lane 1: Rat Liver Tissue Lysate at 50ug. Lane 2: Rat Ovary Tissue Lysate at 50ug. Lane 3: HELA Whole Cell Lysate at 40ug. Predicted bind size: 77KD. Observed bind size: 77KD
图像 2 :
MyBioSource MBS177799 图像 2
Anti- TGM2 Picoband antibody, MBS177799, IHC(P). IHC(P): Mouse Spleen Tissue
图像 3 :
MyBioSource MBS177799 图像 3
Anti- TGM2 Picoband antibody, MBS177799, IHC(P). IHC(P): Rat Spleen Tissue
产品信息
目录号 :
MBS177799
产品类型 :
抗体
产品全称 :
抗TGM2抗体
产品简称 :
[TGM2]
产品名称同义词 :
[Protein-glutamine gamma-glutamyltransferase 2; ALPHA SUBUNIT; C polypeptide; EC 2.3.2.13; G alpha h; G protein alpha subunit Gh class; G[a]h; Gh CLASS G ALPHA h; GNAH; GNAH G PROTEIN; Guanine nucleotide binding protein H polypeptide; H POLYPEPTIDE; Protein glutamine gamma glutamyltransferase 2; Protein glutamine gamma glutamyltransferase; Protein-glutamine gamma-glutamyltransferase 2; TG 2; TG(C); TG2; TGase C; TGase H; TGase-2; TgaseII; TGC; TGC GUANINE NUCLEOTIDE BINDING PROTEIN; TGM 2; TGM2; TGM2_HUMAN; Tissue transglutaminase; Tissue type transglutaminase; Transglutaminase 2; Transglutaminase 2 C polypeptide; Transglutaminase C; Transglutaminase H; Transglutaminase-2; tTG; tTGas antibody; transglutaminase 2]
其他名称 :
[protein-glutamine gamma-glutamyltransferase 2 isoform a; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine gamma-glutamyltransferase 2; transglutaminase 2; Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2]
产品基因名称 :
[TGM2]
其他基因名称 :
[TGM2;TGM2;TGC;TG(C);TG(C);TGC;TGase C;TGase H;TGase-2]
UniProt数据库进入名 :
TGM2_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
687
特异性 :
No cross reactivity with other proteins.
纯度 :
免疫原亲和纯化
形式 :
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
储存稳定性 :
At -20° for one year. After reconstitution, at 4°C for one month. It can also be aliquoted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化)福尔马林/石蜡
应用笔记 :
Western Blot . Concentration: 0.1-0.5 ug/ml. Tested Species: Human, Rat. Immunohistochemistry (Paraffin-embedded Section) . Concentration: 0.5-1 ug/ml. Tested Species: Human, Mouse, Rat. Antigen Retrieval: By Heat. Immunohistochemistry (Frozen Section): . Concentration: 0.5-1 ug/ml. Tested Species: Human, Mouse, Rat. . WB: The detection limit for TMG2 is approximately 0.1 ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0 for 20 mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫组化(免疫组化)
image3头 :
免疫组化(免疫组化)
image4头 :
免疫组化(免疫组化)
image4描述 :
Anti- TGM2 Picoband antibody, MBS177799, IHC(P). IHC(P): Human Intestinal Cancer Tissue
image5头 :
免疫组化(免疫组化)
image5描述 :
Anti- TGM2 Picoband antibody, MBS177799, IHC(P). IHC(P): Human Mammary Cancer Tissue
其它信息1 :
Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human TGM2 (7-34aa LERCDLELETNGRDHHTADLCREKLVVR), different from the related mouse sequence by five amino acids. Ig Type: Rabbit IgG
其他信息2 :
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
产品描述 :
Description: Rabbit IgG polyclonal antibody for Protein-glutamine gamma-glutamyltransferase 2(TGM2) detection. Tested with WB, IHC-P, IHC-F in Human;Mouse;Rat. Background: Tissue transglutaminase, also called TGC, is a 78-kDa, calcium dependent enzyme of the protein-glutamine gamma-glutamyltransferases family. By fluorescence in situ hybridization (FISH), this gene is mapped in 20q11.23. Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease.
产品引用 :
1. Antonyak, M. A., Jansen, J. M., Miller, A. M., Ly, T. K., Endo, M., Cerione, R. A. Two isoforms of tissue transglutaminase mediate opposing cellular fates. Proc. Nat. Acad. Sci. 103: 18609-18614, 2006. 2. Mastroberardino, P. G., Iannicola, C., Nardacci, R., Bernassola, F., de Laurenzi, V., Melino, G., Moreno, S., Pavone, F., Oliverio, S., Fesus, L., Piacentini, M. 'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease. Cell Death Differ. 9: 873-880, 2002. 3. Priglinger, S. G., May, C. A., Neubauer, A. S., Alge, C. S., Schoenfeld, C.-L., Kampik, A., Welge-Lussen, U. Tissue transglutaminase as a modifying enzyme of the extracellular matrix in PVR membranes. Invest. Ophthal. Vis. Sci. 44: 355-364, 2003.
NCBI GI登录号 :
39777597
NCBI登录号 :
NP_004604.2
NCBI基因登录号 :
NM_004613.3
UniProt数据库登录号 :
P21980
NCBI信号通路 :
Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Thromboxane A2 Receptor Signaling Pathway (138060)
NCBI总结 :
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
TGM2: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described. Protein type: EC 2.3.2.13; Transferase. Chromosomal Location of Human Ortholog: 20q12. Cellular Component: cytosol; endoplasmic reticulum; focal adhesion; intrinsic to plasma membrane; mitochondrion. Molecular Function: metal ion binding; protein binding; protein-glutamine gamma-glutamyltransferase activity. Biological Process: apoptotic cell clearance; elevation of mitochondrial calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); peptide cross-linking; positive regulation of apoptosis; positive regulation of cell adhesion; reduction of endoplasmic reticulum calcium ion concentration
尺寸1 :
0.1毫克
价格1 :
315美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。