抗体

Anti-human CD38 Antibody APC Conjugated, Flow Validated

MBS178890

25试验

160美元

单克隆

小鼠

APC

[OKT10]

流式细胞仪, 流式细胞仪

抗体

Anti-human CD38 Antibody APC Conjugated, Flow Validated

[CD38]

[ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 3.2.2.6; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2.4.99.20; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD38; CD38]

[ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; CD38 molecule; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20); 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD_antigen: CD38]

[CD38]

[CD38;CD38;ADPRC1;ADPRC 1;ADPRC 1;环磷酸腺苷核糖水解酶1]

单克隆

IgG1, k

[OKT10]

小鼠

人类

122

蛋白质A纯化

液体;PBS, pH7.2, 0.09% NaN3和0.2%(w/v)BSA

0.5-1.0mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Store at 4°C and protect from prolonged exposure to light. Do not freeze.

流式细胞仪(FC/流式细胞仪)

Each lot of this antibody has been pre-titrated and tested by flow cytometric analysis of human PBMCs such that 5 ul of this product is sufficient for staining 1 million cells in a 100 ul staining volume or 100 ul whole blood. It is recommended that antibody reactivity be empirically titrated for optimal performance in the application of interest. User needs to optimize the dilution ration for this antibody.

试验数据

Conjugate: APC

Immunology; Adaptive Immunity; B Cells; Stem Cells; Hematopoietic Progenitors; Hematopoietic Stem Cells; Human Lineage Negative; Surface Molecules; Lymphoid; B Lymphocytic Lineage; T Lymphocytic Lineage; nk cell lineage; Myeloid; monocytic lineage; Immuno

Description: Mouse Monoclonal Anti-human CD38 APC Conjugated, designed for Flow Cytometry and validated by Flow Cytometry using Human cells. Introduction: CD38 is a type II transmembrane glycoprotein of 45 kDa with a protein core of 35 kDa. The CD38 antigen is expressed on essentially all pre-B lymphocytes, plasma cells, and thymocytes. It is also present on activated T lymphocytes, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. The antigen is expressed during the early stages of T- and B-lymphocyte differentiation, is lost during the intermediate stages of maturation, and then reappears during the final stages of maturation. The CD38 antigen is expressed on 90% of CD34+ cells, and is not expressed on pluripotent stem cells. Coexpression of CD38 antigen on CD34+ cells indicates lineage commitment of those cells. CD38 is a counter-receptor of CD31. It is also expressed in T- and B-acute lymphoblastic leukemia (ALL), Burkitts lymphoma, multiple myeloma, acute myeloid leukemia (AML), and chronic lymphocytic leukemia (CLL). The OKT10 antibody directed against human CD38 antigen. This antibody is routinely tested by flow cytometric analysis. Flow cytometry and other applications were tested during antibody development by CapricoBio or are reported in the literature.

38454326

NP_001766.2

NM_001775.3

P28907

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Metabolic Pathways (132956); Nicotinate And Nicotinamide Metabolism Pathway (83014); Nicotinate And Nicotinamide Metabolism Pathway (400); Oxytocin Signaling Pathway (952859)

The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

25试验

160美元

100试验

255

200试验

400