抗体

抗CCR5(NT)抗体

MBS194047

0.1毫克

370美元

多克隆

兔

未共轭

抗体

抗CCR5(NT)抗体

CCR5(NT)

Anti-CCR5 (NT); HIV Co-Receptor CCR5 (NT)

CCR5

兔

Anti-CCR5 (NT) [Rabbit antibody to peptide corresponding to aa 6-20 of human CCR5.]. This antibody recognizes human CCR5 (40 kD).

100微克IgG在PBS, pH值7.4, 经免疫亲和层析纯化

This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

Immunoblot

Immunoblotting: use at 1:1,000-1:2,000 dilution. Positive control: Whole cell lysate from THP-1 cells.

Antigen: Peptide corresponding to aa 6-20 of human CCR5.

Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

传染病学抗体

Human immunodeficiency virus (HIV) and related viruses require coreceptors in addition to CD4 to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, Bonzo, GPR1, and V28, have been identified as HIV coreceptors. Among them, CCR5 is a principal coreceptor for macrophageand dual-tropic HIV-1 strains. CCR5 is required for infection by HIV-1, HIV-2, and SIV. The beta -chemokines RANTES, MIP-1 alpha , and MIP-1 beta are the ligands for CCR5 and prevent infection by macrophage-tropic HIV-1. CCR5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV binding sites. Messenger RNA for CCR5 is expressed in lymphoid cells and tissues.

220979398

ACL97978.1

Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Salmonella Infection Pathway (375172); Salmonella Infection Pathway (375149)

0.1毫克

370美元