抗体

抗CX3C趋化因子受体1(EL)抗体

MBS194052

0.1毫克

360美元

多克隆

兔

未共轭

抗体

抗CX3C趋化因子受体1(EL)抗体

CX3C趋化因子受体1(EL)

Anti-CX3CR1 (EL); HIV Co-Receptor CX3CR1 (EL)

CX3C chemokine receptor 1; CX3C chemokine receptor 1; CX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; OTTHUMP00000209587; OTTHUMP00000209588; OTTHUMP00000209589; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1; chemokine (C-X3-C motif) receptor 1; Beta chemokine receptor-like 1; CMK-BRL-1; CMK-BRL1; Fractalkine receptor; G-protein coupled receptor 13; V28

CX3C趋化因子受体1;CX3C趋化因子受体1;V28;CCRL1;GPR13;CMKDR1;GPRV28;CMKBRL1;CMKBRL1;GPR13

CX3C1_HUMAN

兔

Anti-CX3CR1 (EL) [Rabbit antibody to peptide corresponding to aa 175-189 of human CX3CR1. The sequence is identical to that of rat CX3CR1 and differs from that of mouse CX3CR1 by one amino acid.]. This antibody recognizes human, mouse and rat CX3CR1 (50 kD).

100微克IgG在PBS, pH值7.4, 经免疫亲和层析纯化

This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

Immunoblot

Immunoblotting: use at 1:500 dilution. Positive control: Whole cell lysate of THP-1 cells.

Antigen: Peptide corresponding to aa 175- 189 of human CX3CR1. The sequence is identical to that of rat CX3CR1 and differs from that of mouse CX3CR1 by one amino acid.

Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.

传染病学抗体

CX3CR1 is one of the chemokine receptors that are required as co-receptors for HIV infection. The genes encoding human, murine, and rat CX3CR1 have been cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. This transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and was renamed CX3CR1. Recently, CX3CR1 was found to serve as a coreceptor for HIV- 1 and HIV-2 envelope fusion and virus infection, which can be inhibited by factalkine. CX3CR1 mediates leukocyte migration and adhesion and is expressed in a variety of human tissues and cell lines.

1351394

P49238.1

P49238

40,396 Da

Chemokine Receptors Bind Chemokines Pathway 106359!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!GPCR Ligand Binding Pathway 161020!!GPCRs, Class A Rhodopsin-like Pathway 198886!!Peptide GPCRs Pathway 198897!!Peptide Ligand-binding Receptors Pathway 106358

Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]

Function: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. Subunit structure: Interacts with human respiratory syncytial virus (HRSV) protein G; this interaction modulates host immune response. Interacts with HIV-1 envelope polyprotein gp160. Ref.9. Subcellular location: Cell membrane; Multi-pass membrane protein. Tissue specificity: Expressed in lymphoid and neural tissues. Polymorphism: Variations in CX3CR1 are associated with rapid progression to AIDS [. MIM:609423]. Increased susceptibility to HIV infection and rapid progression to AIDS are associated with the Ile-249/Met-280 haplotype. Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

0.1毫克

360美元