产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
抗CX3C趋化因子受体1(NT)抗体
目录 :
MBS194053
规格 :
0.1毫克
价格 :
370美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹
更多信息或购买 :
产品信息
目录号 :
MBS194053
产品类型 :
抗体
产品全称 :
抗CX3C趋化因子受体1(NT)抗体
产品简称 :
CX3C趋化因子受体1(NT)
产品名称同义词 :
Anti-CX3CR1 (NT); HIV Co-Receptor CX3CR1 (NT)
其他名称 :
CX3C chemokine receptor 1; CX3C chemokine receptor 1; CX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; OTTHUMP00000209587; OTTHUMP00000209588; OTTHUMP00000209589; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1; chemokine (C-X3-C motif) receptor 1; Beta chemokine receptor-like 1; CMK-BRL-1; CMK-BRL1; Fractalkine receptor; G-protein coupled receptor 13; V28
其他基因名称 :
CX3C趋化因子受体1;CX3C趋化因子受体1;V28;CCRL1;GPR13;CMKDR1;GPRV28;CMKBRL1;CMKBRL1;GPR13
UniProt数据库进入名 :
CX3C1_HUMAN
宿主 :
特异性 :
Anti-CX3CR1 (NT) [Rabbit antibody to peptide corresponding to aa 2-21 of human CXCR1. The sequence differs from mouse and rat CX3CR1 by four amino acids.]. This antibody recognizes human, mouse and rat CX3CR1 (50 kD).
形式 :
100微克IgG在PBS, pH值7.4, 经免疫亲和层析纯化
储存稳定性 :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
检测过的应用 :
Immunoblot
应用笔记 :
Immunoblotting: use at 1:500-1:2,000 dilution. Positive control: Tissue lysate from human spleen.
其它信息1 :
Antigen: Peptide corresponding to aa 2-21 of human CX3CR1. The sequence differs from mouse and rat CX3CR1 by four amino acids.
其他信息2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
产品种类 :
传染病学抗体
产品描述 :
CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, murine, and rat CX3CR1 have been cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. CX3CR1 was recently identified as the receptor for the chemokine fractalkine. CX3CR1 mediates leukocyte migration and adhesion and is expressed in a variety of human tissues and cell lines.
NCBI GI登录号 :
1351394
NCBI登录号 :
P49238.1
UniProt数据库登录号 :
P49238
NCBI分子量 :
40,396 Da
NCBI信号通路 :
Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Peptide GPCRs Pathway (198897); Peptide Ligand-binding Receptors Pathway (106358)
NCBI总结 :
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]
UniProt数据库总结 :
CX3CR1: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. Defects in CX3CR1 are a cause of susceptibility to age- related macular degeneration type 12 (ARMD12). ARMD12 is a form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Receptor, cytokine; Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral; GPCR, family 1; Receptor, GPCR. Chromosomal Location of Human Ortholog: 3p21.3. Cellular Component: neuron projection; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane. Molecular Function: protein binding; chemokine receptor activity; C-X3-C chemokine receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of angiogenesis; cerebral cortex cell migration; viral reproduction; response to wounding; cellular defense response; cell adhesion; chemotaxis; negative regulation of cell migration; macrophage chemotaxis; microglial cell activation during immune response. Disease: Macular Degeneration, Age-related, 12; Coronary Heart Disease, Susceptibility To, 1; Human Immunodeficiency Virus Type 1, Susceptibility To
尺寸1 :
0.1毫克
价格1 :
370美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。