产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
抗趋化因子受体4(EL)抗体
目录 :
MBS194054
规格 :
0.1毫克
价格 :
370美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹
更多信息或购买 :
产品信息
目录号 :
MBS194054
产品类型 :
抗体
产品全称 :
抗趋化因子受体4(EL)抗体
产品简称 :
趋化因子受体4(EL)
产品名称同义词 :
Anti-CXCR4 (EL); HIV Co-Receptor CXCR4 (EL)
其他名称 :
CXCR4; C-X-C chemokine receptor type 4; C-X-C chemokine receptor type 4; fusin; CXC-R4; CXCR-4; CD184 antigen; SDF-1 receptor; OTTHUMP00000204154; OTTHUMP00000204155; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; chemokine (C-X-C motif) receptor 4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; NPYRL; Stromal cell-derived factor 1 receptor
其他基因名称 :
趋化因子受体4;趋化因子受体4;FB22;HM89;LAP3;LCR1;NPYR;WHIM;CD184;LESTR;NPY3R;NPYRL;HSY3RR;NPYY3R;D2S201E
UniProt数据库进入名 :
CXCR4_HUMAN
宿主 :
特异性 :
Anti-CXCR4 (EL) [Rabbit antibody to peptide corresponding to aa 182-196 in the second extracellular loop of human CXCR4.]. This antibody recognizes human and mouse CXCR4 (40 kD).
形式 :
100微克IgG在PBS, pH值7.4, 经免疫亲和层析纯化
储存稳定性 :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
检测过的应用 :
Immunoblot
应用笔记 :
Immunoblotting: use at 1:500-1:1,000 dilution. Positive control: Whole cell lysate from HeLa cells.
其它信息1 :
Antigen: Peptide corresponding to aa 182- 196 in the second extracellular loop (EL) of human CXCR4.
其他信息2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
产品种类 :
传染病学抗体
产品描述 :
Human immunodeficiency virus (HIV) and related viruses require coreceptors in addition to CD4 to infect target cells. Some G proteincoupled receptors in the chemokine receptor family, including CCR5, CXCR4, CCR3, CCR2b, and CCR8 in the chemokine receptor family, have been identified as HIV coreceptors. CXCR4 (also called Fusin, LESTR, HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD4-independent infection by HIV-2. The alpha-chemokine SDF-1 is the ligand for EXCR4 and prevents infection by T-cell tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. The aminoterminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites. CXCR4 messenger RNA levels correlate with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 may block HIV-1 and HIV-2 infection of human target cells.
NCBI GI登录号 :
3059120
NCBI登录号 :
CAA12166.1
UniProt数据库登录号 :
P61073
NCBI分子量 :
39,746 Da
NCBI信号通路 :
Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Binding And Entry Of HIV Virion Pathway (105986); CXCR4-mediated Signaling Events Pathway (137910); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460)
NCBI总结 :
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
UniProt数据库总结 :
CXCR4: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Monomer. Can form dimers. Interacts with CD164. Interacts with HIV-1 surface protein gp120 and Tat. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with human cytomegalovirus/HHV- 5 protein UL78. Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR. Chromosomal Location of Human Ortholog: 2q21. Cellular Component: cell surface; lysosome; early endosome; cytoplasmic membrane-bound vesicle; leading edge; integral to membrane; intercellular junction; growth cone; late endosome; cytoplasm; plasma membrane; cytoplasmic vesicle; external side of plasma membrane. Molecular Function: G-protein coupled receptor activity; viral receptor activity; protein binding; ubiquitin binding; cytokine binding; ubiquitin protein ligase binding; myosin light chain binding; coreceptor activity; actin binding; C-X-C chemokine receptor activity. Biological Process: entry of virus into host cell; regulation of chemotaxis; viral reproduction; apoptosis; activation of MAPK activity; neuron migration; motor axon guidance; regulation of cell migration; germ cell development; T cell proliferation; elevation of cytosolic calcium ion concentration; germ cell migration; dendritic cell chemotaxis; positive regulation of oligodendrocyte differentiation; inflammatory response; neutrophil activation; response to virus; calcium-mediated signaling; patterning of blood vessels; G-protein coupled receptor protein signaling pathway; ameboidal cell migration; myelin maintenance; response to hypoxia; entry into host cell; brain development. Disease: Whim Syndrome
尺寸1 :
0.1毫克
价格1 :
370美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。