产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
抗SODD(NT)抗体
目录 :
MBS194141
规格 :
0.1毫克
价格 :
370美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹
更多信息或购买 :
产品信息
目录号 :
MBS194141
产品类型 :
抗体
产品全称 :
抗SODD(NT)抗体
产品简称 :
SODD(NT)
产品名称同义词 :
抗SODD(NT);SODD(NT)
其他名称 :
silencer of death domains; BAG family molecular chaperone regulator 4; BAG family molecular chaperone regulator 4; OTTHUMP00000225745; OTTHUMP00000225746; silencer of death domains; bcl-2-associated athanogene 4; BAG-family molecular chaperone regulator-4; BCL2-associated athanogene 4; Bcl-2-associated athanogene 4; Silencer of death domains
其他基因名称 :
BAG4;BAG4;SODD;BAG-4;DKFZp586O2022;SODD
UniProt数据库进入名 :
BAG4_HUMAN
宿主 :
特异性 :
Anti-SODD (NT) [Rabbit antibody to peptide corresponding to aa 2-16 of human SODD. Recognizes human, mouse, and rat SODD.]. This antibody recognizes human, mouse, and rat SODD (60 kD).
形式 :
100微克IgG在PBS, pH值7.4, 经免疫亲和层析纯化
储存稳定性 :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
检测过的应用 :
Immunoblot
应用笔记 :
Immunoblotting : use at 1:500-1:2,000 dilution. Positive control: Whole cell lysate from HeLa or THP-1 cells.
其它信息1 :
Antigen: Peptide corresponding to aa 2-16 of human SODD.
其他信息2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
产品种类 :
凋亡抗体
产品描述 :
Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain-containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. A novel TNFR1- interacting protein was recently identified and designated SODD (silencer of death domains). SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD to engage in the active TNF-R1 complex, thus activating TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.
NCBI GI登录号 :
4160014
UniProt数据库登录号 :
O95429
NCBI分子量 :
49,594 Da
NCBI信号通路 :
Ceramide Signaling Pathway (138023); HIV-1 Nef: Negative Effector Of Fas And TNF-alpha Pathway (137995); TNF Receptor Signaling Pathway (138053); TNF-alpha/NF-kB Signaling Pathway (198884)
NCBI总结 :
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq]
UniProt数据库总结 :
BAG4: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Apoptosis. Chromosomal Location of Human Ortholog: 8p11.23. Cellular Component: plasma membrane; nucleus; cytosol. Molecular Function: protein binding; chaperone binding; receptor signaling protein activity. Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of cell adhesion; protein folding; positive regulation of actin filament polymerization; protein heterooligomerization; positive regulation of stress fiber formation; positive regulation of peptidyl-serine phosphorylation; negative regulation of apoptosis
尺寸1 :
0.1毫克
价格1 :
370美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。