产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
抗存活素(NT)抗体
目录 :
MBS194145
规格 :
0.1毫克
价格 :
370美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
应用 :
免疫印迹
更多信息或购买 :
产品信息
目录号 :
MBS194145
产品类型 :
抗体
产品全称 :
抗存活素(NT)抗体
产品简称 :
存活素(NT)
产品名称同义词 :
抗存活素(NT);存活素(NT)
其他名称 :
baculoviral IAP repeat-containing protein 5; Baculoviral IAP repeat-containing protein 5; baculoviral IAP repeat-containing protein 5; survivin; apoptosis inhibitor survivin; Apoptosis inhibitor survivin
其他基因名称 :
BIRC5;BIRC5;BIRC5
UniProt数据库进入名 :
BIRC5_CANFA
宿主 :
特异性 :
Anti-Survivin (NT) [Rabbit antibody to peptide corresponding to aa 1-12 of human survivin.]. This antibody recognizes human survivin (17 kD).
形式 :
100微克IgG在200微升PBS, pH值7.4, 经免疫亲和层析纯化
储存稳定性 :
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
检测过的应用 :
Immunoblot
应用笔记 :
Immunoblotting: use at 1:500-1:1,000 dilution. Positive control: MOLT4 cells.
其它信息1 :
Antigen: Peptide corresponding to aa 1-12 of human survivin.
其他信息2 :
Stabilizer: None. Preservatives: 0.02% sodium azide. Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
产品种类 :
凋亡抗体
产品描述 :
Apoptosis is related to many diseases and is triggered by a variety of stimuli including members of the TNF family. Apoptosis can be prevented by the inhibitor of apoptosis proteins (IAPs). IAPs constitute a conserved gene family that binds to and inhibits cell death proteases. A novel IAP has been identified and designated survivin. Survivin interacts with the processed form of caspase-3 and inhibits its proteolytic activity. Survivin is expressed predominantly in tissues of embryos, transformed cell lines, and many human cancers.
NCBI GI登录号 :
50978646
NCBI登录号 :
NP_001003019.1
NCBI基因登录号 :
NM_001003019.1
UniProt数据库登录号 :
Q8I009
NCBI分子量 :
16,271 Da
NCBI信号通路 :
Colorectal Cancer Pathway (84152); Colorectal Cancer Pathway (518); Pathways In Cancer (84151)
UniProt数据库总结 :
Function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Inhibitor of caspase-3 and caspase-7. Subunit structure: Monomer or homodimer. Exist as a homodimer in the apo state and as a monomer in the CPC-bound state. By similarity. When phosphorylated, interacts with HBXIP; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B. Interacts with JTB. Interacts with CDCA8 and INCENP; interaction is direct. Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin. Subcellular location: Cytoplasm. By similarity. Nucleus. By similarity. Chromosome centromere. By similarity. Cytoplasm cytoskeleton spindle. By similarity. Note: Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes. By similarity. UniProtKB O15392. Domain: The BIR repeat is necessary and sufficient for HBXIP binding. Post-translational modification: Ubiquitination is required for centrosomal targeting. By similarity.In vitro phosphorylation at Thr-117 by AURKB/STK12 prevents interaction with INCENP and localization to mitotic chromosomes. Sequence similarities: Belongs to the IAP family.Contains 1 BIR repeat.
尺寸1 :
0.1毫克
价格1 :
370美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。