抗体

c-myc Affinity Purified Antibody, Agarose Immobilized

MBS194205

0.1毫克

335美元

多克隆

山羊

琼脂糖

抗体

c-myc Affinity Purified Antibody, Agarose Immobilized

Agarose Immobilized Goat anti-c-myc

Agarose Immobilized Goat anti-c-myc

c-myc; Myc proto-oncogene protein; myc proto-oncogene protein; OTTHUMP00000158589; OTTHUMP00000227763; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelocytomatosis viral oncogene homolog; v-myc avian myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor; v-myc myelocytomatosis viral oncogene homolog (avian); Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64

MYC;MYC;MRTL;c-Myc;bHLHe39;BHLHE39

MYC_HUMAN

山羊

439

Agarose Immobilized Goat anti-c-myc

100微克抗体/200微升凝胶

Store at 4 degree C; stable for one year

免疫沉淀

Immunoprecipitation: 15 to 25 ul of gell slurry per 0.1 to 1 mg of protein lysate or extract

Antigen: c-myc (EKLISEEDL) coupled to KLH. Antibody coupled to agarose beads using a cyanogen bromide method.

Buffer: 0.01M Phosphate, pH 7.2, 0.1M NaCl. Stabilizer: None. Preservatives: 0.1% sodium azide

表位标签抗体

396512

CAA46984.1

Q6LBK7

48,804 Da

Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Apoptosis Pathway (198797); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); C-MYB Transcription Factor Network Pathway (138073); C-MYC Pathway (169344); CD40/CD40L Signaling Pathway (138061); Cell Cycle, Mitotic Pathway (105765); Cell Cycle Pathway (83054)

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq]

Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes. Protein type: DNA-binding; Transcription factor; Oncoprotein; Nucleolus. Chromosomal Location of Human Ortholog: 8q24.21. Cellular Component: nucleoplasm; protein complex; nucleolus; cytosol; nucleus. Molecular Function: protein dimerization activity; protein binding; DNA binding; protein complex binding; transcription factor binding; transcription factor activity. Biological Process: oxygen transport; cellular iron ion homeostasis; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; chromosome organization and biogenesis; positive regulation of fibroblast proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; response to gamma radiation; cell cycle arrest; response to drug; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; transcription, DNA-dependent; regulation of telomere maintenance; MAPKKK cascade; negative regulation of cell division; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; chromatin remodeling; negative regulation of fibroblast proliferation; ureteric bud branching; regulation of gene expression; energy reserve metabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; positive regulation of epithelial cell proliferation; negative regulation of apoptosis. Disease: Burkitt Lymphoma

0.1毫克

335美元