抗体

alpha突触核蛋白(61-95氨基酸)抗体(克隆5C2)

MBS200019

0.05毫升

240美元

单克隆

小鼠

未共轭

5C2

免疫印迹, 酶联免疫吸附测定, 酶免疫法

抗体

alpha突触核蛋白(61-95氨基酸)抗体(克隆5C2)

alpha突触核蛋白

SNCA; NACP; PARK1; alpha-Synuclein Delta-NAC; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; Alpha-synuclein; Alpha synuclein; Alpha-synuclein; isoform NACP140; alphaSYN; MGC105443; MGC110988; MGC127560; MGC64356; Non A beta component of AD amyloid; Non A4 component of amyloid precursor; Non-A-beta component of alzheimers disease amyloid; precursor of; PARK 1; PARK 4; PARK4; Parkinson disease familial 1; PD 1; PD1; Snca synuclein; alpha (non A4 component of amyloid precursor); Synuclein alpha; Synuclein; alpha (non A4 component of amyloid precursor)

alpha-synuclein isoform NACP140; Alpha-synuclein; alpha-synuclein; non A-beta component of AD amyloid; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor); Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP

SNCA;SNCA;PD1;NACP;PARK1;PARK4;NACP;PARK1;NACP

SYUA_HUMAN

单克隆

IgG1, k

5C2

小鼠

人类

140

By protein-G affinity chromatography

液体。 用品在磷酸盐缓冲液(pH值7.4)含0.1％叠氮化钠

1毫克/毫升

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

ELISA (EIA), Western Blot (WB) (Recombinant protein,Cell lysate)

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1:2,000. This antibody (5C2) has the specificity against the NAC domain (61-95aa) of alpha-synuclein. Recommended starting dilution is 1:1,000.

Antigen Species: Human. Clone: Anti-human alpha-Synuclein mAb, clone 5C2, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human alpha-synuclein protein. This antibody specifically recognizes alpha-synuclein only, particularly the NAC domain of alpha-synuclein. Immunogen: Recombinant human alpha-synuclein (61-95) purified from E Coli

神经科学

alpha-synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Specially, the non-Abeta component of amyloid plaques (NAC, amino acids 61-95) is a highly amyloidogenic peptide consisting of 35 amino acids which was first identified associated with senile plaques in the Alzheimer's disease brain.

Jakes, R., et al. (1994) FEBS lett. 345:27-32 Ueda, k., et al. (1993) Proc. Natl.Acad. Sci. USA 90:11282-11286 kim, J. (1997) Molecules and Cells 7:78-83 Paik, S. R., et al. (1997) Arch. Biochem. Biophys. 344:325-334.

4507109

NP_000336

NM_000345.3

13,109 Da

Alpha-synuclein Signaling Pathway (137913); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Amyloids Pathway (366238); Disease Pathway (530764); EGFR1 Signaling Pathway (198782); Parkin-Ubiquitin Proteasomal System Pathway (700638); Parkinson's Disease Pathway (83098); Parkinsons Disease Pathway (705377)

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]

SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson s disease. A major component of amyloid plaques in the brains of patients with Alzheimer s disease. Two alternatively spliced isoforms transcripts have been identified. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 4q21. Cellular Component: Golgi apparatus; nuclear outer membrane; mitochondrion; rough endoplasmic reticulum; lysosome; fibril; extracellular region; terminal button; cell cortex; inclusion body; cytosol; mitochondrial respiratory chain complex I; actin cytoskeleton; synaptic vesicle; platelet alpha granule membrane; growth cone; perinuclear region of cytoplasm; axon; cytoplasm; plasma membrane; ribosome; cell junction; nucleus. Molecular Function: identical protein binding; protein domain specific binding; zinc ion binding; histone binding; kinesin binding; ferrous iron binding; microtubule binding; caspase inhibitor activity; beta-tubulin binding; magnesium ion binding; phosphoprotein binding; protein N-terminus binding; Hsp70 protein binding; oxidoreductase activity; calcium ion binding; dynein binding; protein binding; copper ion binding; phospholipase binding; phospholipid binding; fatty acid binding; tau protein binding; alpha-tubulin binding. Biological Process: regulation of long-term neuronal synaptic plasticity; negative regulation of serotonin uptake; regulation of acyl-CoA biosynthetic process; positive regulation of apoptosis; adult locomotory behavior; mitochondrial membrane organization and biogenesis; negative regulation of norepinephrine uptake; microglial cell activation; response to lipopolysaccharide; positive regulation of endocytosis; negative regulation of caspase activity; dopamine biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of monooxygenase activity; fatty acid metabolic process; regulation of dopamine secretion; positive regulation of neurotransmitter secretion; negative regulation of histone acetylation; negative regulation of dopamine uptake; calcium ion homeostasis; response to magnesium ion; negative regulation of exocytosis; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; phospholipid metabolic process; receptor internalization; fibril organization and biogenesis; synapse organization and biogenesis; dopamine uptake; response to iron(II) ion; negative regulation of neuron apoptosis; positive regulation of receptor recycling; aging; caspase activation; response to drug; neutral lipid metabolic process; protein destabilization; regulation of macrophage activation; negative regulation of microtubule polymerization; regulation of glutamate secretion; positive regulation of peptidyl-serine phosphorylation; negative regulation of dopamine metabolic process; organelle ATP synthesis coupled electron transport; regulation of locomotion; synaptic vesicle endocytosis; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential; negative regulation of transporter activity; negative regulation of apoptosis. Disease: Parkinson Disease 4, Autosomal Dominant; Dementia, Lewy Body; Parkinson Disease 1, Autosomal Dominant

0.05毫升

240美元

0.1毫升

315