抗体

干扰素调节因子3抗体(克隆3F10)

MBS200059

0.05毫升

240美元

单克隆

小鼠

未共轭

3F10

免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫沉淀, 酶免疫法

抗体

干扰素调节因子3抗体(克隆3F10)

干扰素调节因子3

IRF3;干扰素调节因子3;IRF-3;干扰素调节因子3;IRF 3

interferon regulatory factor 3 isoform 1; Interferon regulatory factor 3; interferon regulatory factor 3; interferon regulatory factor 3

IRF3;IRF3;IRF-3

IRF3_HUMAN

单克隆

IgG1, k

3F10

小鼠

人类

427

By protein-G affinity chromatography

液体。 用品在磷酸盐缓冲液(pH值7.4)含10% 甘油, 0.01% 叠氮化钠

1毫克/毫升

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

ELISA (EIA), Western Blot (WB) (Cell lysate), Immunoprecipitation (IP), Immunofluorescence (IF)

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000 ~ 2,000. Recommended starting dilution is 1:1,000.

Antigen Species: Human. Clone: Anti-human IRF-3 mAb, clone 3F10, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human IRF-3 protein. Immunogen: Recombinant human IRF-3(108-166aa) purified from E Coli

激素&细胞因子

Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is a member of the IRF family, and is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection.

DeFilippis VR et al.,(2006) J Virol 80(2):1032-1037 Pietila TE et al.,(2007) J Immunol 178(1):253-261

4504725

NP_001562

NM_001571.5

12,330 Da

Activated TLR4 Signalling Pathway 106400!!Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway 187088!!Antiviral Mechanism By IFN-stimulated Genes Pathway 530760!!Apoptosis Pathway 198797!!Cytokine Signaling In Immune System Pathway 366171!!Cytosolic DNA-sensing Pathway 125137!!Cytosolic DNA-sensing Pathway 124833!!Cytosolic Sensors Of Pathogen-associated DNA Pathway 576255!!Epstein-Barr Virus Infection Pathway 585562!!Epstein-Barr Virus Infection Pathway 587115

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

0.05毫升

240美元