产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
IL33抗体(克隆4E9)
目录 :
MBS200087
规格 :
0.05毫升
价格 :
240美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
4.00E+09
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS200087
产品类型 :
抗体
产品全称 :
IL33抗体(克隆4E9)
产品简称 :
IL33
产品名称同义词 :
Interleukin 33; DVS27; NF-HEV; NKHEV; C9orf26; IL-33; Interleukin 33 CHROMOSOME 9 OPEN READING FRAME 26; DKFZp586H0523; DVS27 related protein; IL 1F11; IL 33; IL1F11; Interleukin 1 family member 11; INTERLEuKIN 33 NFHEV; Interleukin 33 precursor; Interleukin33; NF HEV; NFHEV; Nuclear factor from high endothelial venules; RP11 575C20.2; il33
其他名称 :
interleukin-33 isoform 1; Interleukin-33; interleukin-33; DVS27-related protein; IL-1F11; IL-33; interleukin-1 family member 11; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules; interleukin 33; Interleukin-1 family member 11; IL-1F11; Nuclear factor from high endothelial venules; NF-HEV
产品基因名称 :
IL33
其他基因名称 :
IL33;IL33;DVS27;IL1F11;NF-HEV;NFEHEV;C9orf26;C9orf26;IL1F11;NFHEV;IL-33;IL-1F11;NF-HEV
UniProt数据库进入名 :
IL33_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG2b, k
克隆 :
4.00E+09
宿主 :
小鼠
反应物种 :
人类
序列长度 :
270
纯度 :
By protein-G affinity chromatography
形式 :
液体。 用品在磷酸盐缓冲液(pH值7.4)含0.1%叠氮化钠
浓度 :
1毫克/毫升
储存稳定性 :
Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.
检测过的应用 :
ELISA (EIA), Western Blot (WB) (Cell lysate)
应用笔记 :
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500.
其它信息1 :
Antigen Species: Human. Clone: Anti-human IL-33 mAb, clone 4E9, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human IL-33 protein. Immunogen: Recombinant human IL-33 (112-270aa) purified from E Coli
产品种类 :
激素&细胞因子
产品描述 :
Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine and intracellular nuclear factor with transcriptional regulatory properties. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1.
产品引用 :
Brint Ek, et al., (2005) J Biol Chem. 20:277(51) Schmitz, et al., (2005) immunity. 23:479 Baekkevold ES, et al., (2003) Am.J.Pathol. 163(1):69-90
NCBI GI登录号 :
15559209
NCBI登录号 :
NP_254274
NCBI基因登录号 :
NM_033439.3
NCBI分子量 :
16,250 Da
NCBI信号通路 :
Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Influenza A Pathway (217173); Influenza A Pathway (217150)
NCBI总结 :
IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011]
UniProt数据库总结 :
IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cytokine. Chromosomal Location of Human Ortholog: 9p24.1. Cellular Component: extracellular space; transport vesicle; chromosome; nucleus. Molecular Function: protein binding; cytokine activity. Biological Process: positive regulation of T-helper 2 type immune response; negative regulation of T-helper 1 type immune response; T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; negative regulation of leukocyte migration; positive regulation of interleukin-4 production; negative regulation of immunoglobulin secretion; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of macrophage activation; positive regulation of inflammatory response
尺寸1 :
0.05毫升
价格1 :
240美元
尺寸2 :
0.1毫升
价格2 :
315
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。