抗体

Cofilin 1 antibody (clone AT1C1)

MBS200127

0.05毫升

240美元

单克隆

小鼠

未共轭

AT1C1

免疫印迹, 酶联免疫吸附测定, 酶免疫法

抗体

Cofilin 1 antibody (clone AT1C1)

Cofilin 1

CFL1; CFL; Cofilin 1; CFL1; CFL; 18 kDa phosphoprotein(p18) 18 kDa phosphoprotein; CFL 1; Cofilin 1; Cofilin 1 non muscle; Cofilin non muscle isoform; P18.

cofilin-1; Cofilin-1; cofilin-1; 18 kDa phosphoprotein; cofilin, non-muscle isoform; epididymis secretory protein Li 15; p18; cofilin 1 (non-muscle); 18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform

CFL1;CFL1;CFL;HEL-S-15;CFL;p18

COF1_HUMAN

单克隆

IgG1, k

AT1C1

小鼠

人类

166

By protein-G affinity chromatography

液体。 用品在磷酸盐缓冲液(pH值7.4)含0.1％叠氮化钠

1毫克/毫升

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

ELISA (EIA), Western Blot (WB) (Tissue, Cell lysate)

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000 ~ 2,000. Recommended starting dilution is 1:1,000.

Antigen Species: Human. Clone: Anti-human Cofilin 1 mAb, clone AT1C1, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Cofilin 1 protein. Immunogen: Recombinant human Cofilin 1 (1-166aa) purified from E Coli

细胞骨架

Cofilin is a family of actin-binding proteins which disassembles actin filaments. It is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.

Mannherz H.G., et al. (2007) J Mol Biol 366(3):745-755 Olsen J.V., et al. (2006) Cell 127(3):635-648 Yang N., et al. (1998) Nature 393(6687):809-812

5031635

NP_005498

NM_005507.2

18,502 Da

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); BDNF Signaling Pathway (712093); CDC42 Signaling Events Pathway (137994); CXCR4-mediated Signaling Events Pathway (137910); Developmental Biology Pathway (477129); EPH-Ephrin Signaling Pathway (1127691); EPHB-mediated Forward Signaling Pathway (1127693); Fc Gamma R-mediated Phagocytosis Pathway (114228)

The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

Cofilin-1: a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues. Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 11q13. Cellular Component: extracellular space; cortical actin cytoskeleton; nuclear matrix; focal adhesion; membrane; cytoplasm; intercellular junction; nucleus; vesicle. Molecular Function: protein binding; actin binding. Biological Process: actin filament depolymerization; axon guidance; platelet activation; positive regulation of actin filament depolymerization; response to virus; cytoskeleton organization and biogenesis; negative regulation of cell size; response to amino acid stimulus; protein amino acid phosphorylation; Rho protein signal transduction; neural fold formation; platelet degranulation; cytokinesis after mitosis; establishment of cell polarity; protein import into nucleus; ephrin receptor signaling pathway; innate immune response; regulation of cell morphogenesis; blood coagulation; actin cytoskeleton organization and biogenesis; neural crest cell migration; negative regulation of apoptosis

0.05毫升

240美元

0.1毫升

315