抗体

Polyclonal Antibody to Hemojuvelin (HJV)

MBS2001619

0.01毫克

130美元

多克隆

兔

未共轭

人类, 小鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 酶免疫法, 免疫组化-石蜡切片

抗体

Polyclonal Antibody to Hemojuvelin (HJV)

Hemojuvelin (HJV)

hemojuvelin; Hemojuvelin; hemojuvelin; RGM domain family member C; repulsive guidance molecule C; hemochromatosis type 2 protein homolog; hemochromatosis type 2 (juvenile) (human homolog); Hemochromatosis type 2 protein homolog; RGM domain family member C

HJV

Hfe2; Hfe2; HJV; DL-M; Rgmc; AI414844; AI789733; hemojuvelin; 2310035L15Rik; 5230400G09Rik; Rgmc

RGMC_MOUSE

多克隆

IgG

兔

人类

420

The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSGSEF-KVYQAEV DNLPVAFEDG SINGGDRPGG SSLSIQTANP GNHVEIQAAY IGTTIIIRQT AGQLSFSIKV AEDVAMAFSA EQDLQLCVGG CPPSQRLSRS ERNRRGAITI DTARRLCKEG LPVEDAYFHS CVFDVLISGD PNFTVAAQAA LEDARAFLPD LEKLHLFPSD AGVPLSSATL LAPLLS

The antibody is a rabbit polyclonal antibody raised against HJV. It has been selected for its ability to recognize HJV in immunohistochemical staining andwestern blotting.

亲和色谱

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.

200微克/毫升

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

免疫细胞化学(免疫细胞化学), 免疫组化(免疫组化)-福尔马林/石蜡, 酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

Western blotting: 1:50-400. Immunocytochemistry in formalin fixed cells: 1:50-500. Immunohistochemistry in formalin fixed frozen section: 1:50-500. Immunohistochemistry in paraffin section: 1:10-100. Enzyme-linked Immunosorbent Assay: 1:100-5000. Optimal working dilutions must be determined by end user.

Immunogen: HJV, Human. Immunogen Information: Recombinant HJV (Lys234~Ser416) with N-terminal His-Tag expressed in E.coli. Accession No.: RPB995Hu01

166295198

NP_081402.3

NM_027126.4

Q7TQ32

Axon Guidance Pathway (926383); Developmental Biology Pathway (926382); Iron Homeostasis Pathway (198312); Netrin-1 Signaling Pathway (926394)

HFE2: Member of the repulsive guidance molecule (RGM) family. Involved in iron metabolism. Acts as a bone morphogenetic protein (BMP) coreceptor. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism. May cooperate with hepcidin to restrict iron absorption in the gut. Could represent the cellular receptor for hepcidin. Defects in HFE2 are the cause of hemochromatosis type 2A (HFE2A); also known as juvenile hemochromatosis (JH). HFE2A is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. It is the consequence of intestinal iron hyperabsorption associated with macrophages that do not load iron. Deleterious mutations of HFE2 reduced HAMP (hepcidin) levels despite iron overload, which normally induces HAMP expression. Belongs to the repulsive guidance molecule (RGM) family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, GPI anchor. Cellular Component: extracellular space; cell surface; membrane; basolateral plasma membrane; plasma membrane. Molecular Function: protein binding; coreceptor activity. Biological Process: BMP signaling pathway; iron ion homeostasis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of BMP signaling pathway

0.01毫克

130美元

0.05毫克

225

0.1毫克

295