抗体

磷酸甘油醛脱氢酶抗体(AT8G4)

MBS200179

0.05毫升

240美元

单克隆

小鼠

未共轭

AT8G4

免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 酶免疫法

抗体

磷酸甘油醛脱氢酶抗体(AT8G4)

磷酸甘油醛脱氢酶

G3PD; GAPD; MGC88685; Glyceraldehyde-3-phosphate dehydrogenase; GAPDH; Glyceraldehyde-3-phosphate dehydrogenase 38 kDa BFA-dependent ADP-ribosylation substrate; Aging-associated gene 9 protein; BARS-38; cb609; EC 1.2.1.12; G3PDH; OCAS; p38 component; Glyceraldehyde 3 phosphate dehydrogenase; KNC-NDS6; MGC102544; MGC102546; MGC103190; MGC103191; MGC105239; MGC127711; OCT1 coactivator in S phase; 38-KD component; OTTHuMP00000174431; OTTHuMP00000174432; wu:fb33a10.

glyceraldehyde-3-phosphate dehydrogenase isoform 1; Glyceraldehyde-3-phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase; aging-associated gene 9 protein; epididymis secretory sperm binding protein Li 162eP; peptidyl-cysteine S-nitrosylase GAPDH; glyceraldehyde-3-phosphate dehydrogenase; Peptidyl-cysteine S-nitrosylase GAPDH (EC:2.6.99.-)

磷酸甘油醛脱氢酶

磷酸甘油醛脱氢酶;磷酸甘油醛脱氢酶;G3PD;GAPD;HEL-S;GAPD;磷酸甘油醛脱氢酶

G3P_HUMAN

单克隆

IgG2b, k

AT8G4

小鼠

人类

335

By protein-G affinity chromatography

液体。 用品在磷酸盐缓冲液(pH值7.4)含0.1％叠氮化钠

1毫克/毫升

Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫荧光(IF)

The antibody has been tested by ELISA, Western blot and Immunofluorescence analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis and Immunofluorescence is 1:500 ~ 10,000. Recommended starting dilution is 1:1,000

Antigen Species: Human. Clone: Anti-human GAPDH mAb, clone AT8G4, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human GAPDH protein. Immunogen: Recombinant human GAPDH (1-335aa) purified from E.coli

Cancer

Multiple roles for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) have been recently appreciated. GAPDH is found in the particulate fractions, such as the nucleus, the mitochondria, and the small vesicular fractions. GAPDH gene expression is specifically increased during programmed neuronal cell death. When cells are exposed to various stressors, dynamic subcellular re-distribution of GAPDH occurs. GAPDH is also involved in various diseases, especially neurodegenerative disorders and cancers. As a membrane protein, GAPDH functions in endocytosis; in the cytoplasm, it is involved in the translational control of gene expression; in the nucleus, it functions in nuclear tRNA export, in DNA replication, and in DNA repair.

Chuang DM, et al. (2005) Annu Rev Pharmacol Toxicol, 45:269-90. Mazzola JL, et al. (2002) Neurotoxicology, 23(4-5):603-9. Sirover MA. (1997) J Cell Biochem, 66(2):133-40.

7669492

NP_002037

NM_002046.5

31,548 Da

Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Biosynthesis Of Amino Acids Pathway 790012!!Biosynthesis Of Amino Acids Pathway 795174!!Carbon Metabolism Pathway 814926!!Carbon Metabolism Pathway 817567!!Disease Pathway 530764!!Gluconeogenesis Pathway 106204!!Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway 413342

This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

0.05毫升

240美元