产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
多克隆抗体粘蛋白1(粘蛋白1)
目录 :
MBS2001934
规格 :
0.01毫克
价格 :
100美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS2001934 图像 1
Western Blot: Sample: Mouse Pancreas Tissue.
图像 2 :
MyBioSource MBS2001934 图像 2
Western Blot: Sample: Recombinant MUC1, Human.
图像 3 :
MyBioSource MBS2001934 图像 3
DAB staining on IHC-P; Samples: Human Kidney Tissue
产品信息
目录号 :
MBS2001934
产品类型 :
抗体
产品全称 :
多克隆抗体粘蛋白1(粘蛋白1)
产品简称 :
[粘蛋白1(粘蛋白1)]
其他名称 :
[mucin-1 isoform 2; Mucin-1; mucin-1; mucin 1, cell surface associated; Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; CA 15-3]
产品基因名称 :
[粘蛋白1]
其他基因名称 :
[粘蛋白1;粘蛋白1;EMA;MCD;PEM;PUM;KL-6;MAM6;MCKD;PEMT;CD227;H23AG;MCKD1;MUC-1;ADMCKD;ADMCKD1;CA 15-3;MUC-1/X;粘蛋白1/ZD;MUC-1/SEC;PUM;MUC-1;CA 15-3;KL-6;PUM;PEM;EMA;粘蛋白1-NT;粘蛋白1甲;粘蛋白1乙]
克隆性 :
多克隆
宿主 :
纯度 :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
形式 :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
浓度 :
0.47毫克/毫升
储存稳定性 :
Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
检测过的应用 :
免疫细胞化学(免疫细胞化学), 免疫组化(免疫组化)-福尔马林/石蜡, 免疫印迹(免疫印迹), 免疫沉淀(免疫沉淀)
应用笔记 :
Western blotting: 0.5-2 ug/mL;1:230-940. Immunohistochemistry: 5-20 ug/mL;1:23-94. Immunocytochemistry: 5-20 ug/mL;1:23-94. Optimal working dilutions must be determined by end user.
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫印迹(免疫印迹)
image3头 :
免疫组化(免疫组化)
image4头 :
免疫组化(免疫组化)
image4描述 :
DAB staining on IHC-P; Samples: Human Kidney Tissue)
其它信息1 :
Organism Species: Homo sapiens (Human). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant MUC1 (Ser1098~Leu1255) expressed in E.coli
NCBI GI登录号 :
67189007
NCBI登录号 :
NP_001018016.1
NCBI基因登录号 :
NM_001018016.2
UniProt数据库登录号 :
P15941
NCBI信号通路 :
IL-7 Signaling Pathway (198857); Metabolism Of Proteins Pathway (106230); O-linked Glycosylation Of Mucins Pathway (530747); Post-translational Protein Modification Pathway (161012); Termination Of O-glycan Biosynthesis Pathway (530748)
NCBI总结 :
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
UniProt数据库总结 :
MUC1: a large cell surface glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. Plays a role in adhesion and cell-cell interactions, metastasis and signaling. May provide a protective layer on epithelial surfaces. Direct or indirect interaction with actin cytoskeleton. Its cytoplasmic tail (MUC1CT) is involved in several signaling pathways, including those involving Ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. MUC1CT also forms complexes with transcription factors, and then translocates to the nucleus by an unknown mechanism, where it is believed to influence the transcription of their target genes. MUC1CT has also been proposed to localize to mitochondrial membranes under conditions of genotoxic stress, where it attenuates the apoptotic pathway in response and confers resistance to apoptosis-inducing drugs. Aberrantly glycosylated forms expressed in human epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Nine alternatively spliced isoforms have been described. Isoforms 5 and 9 are secreted. Isoform 7, expressed only in tumor cells, is a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling. Can bind to GRB2 adapter protein. Protein type: Actin-binding; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Tumor suppressor. Chromosomal Location of Human Ortholog: 1q22. Cellular Component: apical plasma membrane; extracellular exosome; extracellular space; Golgi lumen; integral component of plasma membrane; nuclear chromatin; plasma membrane; vesicle. Molecular Function: p53 binding; protein binding; transcription cofactor activity. Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; negative regulation of cell adhesion mediated by integrin; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of transcription by competitive promoter binding; O-glycan processing; positive regulation of histone H4 acetylation; regulation of transcription from RNA polymerase II promoter in response to stress; stimulatory C-type lectin receptor signaling pathway. Disease: Medullary Cystic Kidney Disease 1
尺寸1 :
0.01毫克
价格1 :
100美元
尺寸2 :
0.02毫克
价格2 :
110
size3 :
0.05毫克
价格3 :
150
size4 :
0.1毫克
price4 :
195
size5 :
0.2毫克
price5 :
270
size6 :
1毫克
price6 :
645
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。