产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Polyclonal Antibody to Procollagen I N-Terminal Propeptide (PINP)
目录 :
MBS2004656
规格 :
0.01毫克
价格 :
125美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 酶免疫法, 免疫组化-石蜡切片
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图像
图像 1 :
MyBioSource MBS2004656 图像 1
Figure. Western Blot: Sample: Recombinant PINP, Human
产品信息
目录号 :
MBS2004656
产品类型 :
抗体
产品全称 :
Polyclonal Antibody to Procollagen I N-Terminal Propeptide (PINP)
产品简称 :
[Procollagen I N-Terminal Propeptide (PINP)]
其他名称 :
[collagen alpha-1(I) chain preproprotein; Collagen alpha-1(I) chain; collagen alpha-1(I) chain; collagen type I alpha 1 chain; Alpha-1 type I collagen]
产品基因名称 :
[PINP]
其他基因名称 :
[COL1A1;COL1A1;OI1;OI2;OI3;OI4;EDSC]
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
人类
序列 :
Antigen: The target peptide sequence is listed below. TKNCPGAEVPEGECCP
特异性 :
The antibody is a rabbit polyclonal antibody raised against PINP. It has been selected for its ability to recognize PINP in immunohistochemical staining andwestern blotting.
纯度 :
亲和色谱
形式 :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
浓度 :
200微克/毫升
储存稳定性 :
Store at 4 degree C for frequent use. Stored at -20 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
检测过的应用 :
免疫细胞化学(免疫细胞化学), 免疫组化(免疫组化)-福尔马林/石蜡, 酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)
应用笔记 :
Western blotting: 1:50-400. Immunocytochemistry in formalin fixed cells: 1:50-500. Immunohistochemistry in formalin fixed frozen section: 1:50-500. Immunohistochemistry in paraffin section: 1:10-100. Enzyme-linked Immunosorbent Assay: 1:100-5000. Optimal working dilutions must be determined by end user.
image1头 :
免疫印迹(免疫印迹)
其它信息1 :
Immunogen: PINP-OVA. Immunogen Information: Synthetic Peptide, PINP conjugated to KLH.
其他信息2 :
Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2049965
产品描述 :
P1NP is the most effective marker of bone formation and is particularly useful for monitoring bone-formation and antiresorptive therapies. Concentrations are increased in patients with various bone diseases, including bone metastases and therapies, which are characterized by increased osteoblastic activity. Moreover, Collagen type I constitutes 90% of bone, but it is also present in many other tissues including liver, skin and tendons.
NCBI GI登录号 :
110349772
NCBI登录号 :
NP_000079.2
NCBI基因登录号 :
NM_000088.3
UniProt数据库登录号 :
P02452
NCBI分子量 :
138,941 Da
NCBI信号通路 :
Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Collagen Biosynthesis And Modifying Enzymes Pathway (645289); Collagen Formation Pathway (645288); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (576262); Focal Adhesion Pathway (198795)
NCBI总结 :
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
UniProt数据库总结 :
COL1A1: Type I collagen is a member of group I collagen (fibrillar forming collagen). Defects in COL1A1 are the cause of Caffey disease (CAFFD); also known as infantile cortical hyperostosis. Caffey disease is characterized by an infantile episode of massive subperiosteal new bone formation that typically involves the diaphyses of the long bones, mandible, and clavicles. The involved bones may also appear inflamed, with painful swelling and systemic fever often accompanying the illness. The bone changes usually begin before 5 months of age and resolve before 2 years of age. Defects in COL1A1 are a cause of Ehlers-Danlos syndrome type 1 (EDS1); also known as Ehlers-Danlos syndrome gravis. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Defects in COL1A1 are the cause of Ehlers-Danlos syndrome type 7A (EDS7A); also known as autosomal dominant Ehlers-Danlos syndrome type VII. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7A is marked by bilateral congenital hip dislocation, hyperlaxity of the joints, and recurrent partial dislocations. Defects in COL1A1 are a cause of osteogenesis imperfecta type 1 (OI1). A dominantly inherited connective tissue disorder characterized by bone fragility and blue sclerae. Osteogenesis imperfecta type 1 is non-deforming with normal height or mild short stature, and no dentinogenesis imperfecta. Defects in COL1A1 are a cause of osteogenesis imperfecta type 2 (OI2); also known as osteogenesis imperfecta congenita. A connective tissue disorder characterized by bone fragility, with many perinatal fractures, severe bowing of long bones, undermineralization, and death in the perinatal period due to respiratory insufficiency. Defects in COL1A1 are a cause of osteogenesis imperfecta type 3 (OI3). A connective tissue disorder characterized by progressively deforming bones, very short stature, a triangular face, severe scoliosis, grayish sclera, and dentinogenesis imperfecta. Defects in COL1A1 are a cause of osteogenesis imperfecta type 4 (OI4); also known as osteogenesis imperfecta with normal sclerae. A connective tissue disorder characterized by moderately short stature, mild to moderate scoliosis, grayish or white sclera and dentinogenesis imperfecta. Genetic variations in COL1A1 are a cause of susceptibility to osteoporosis (OSTEOP); also known as involutional or senile osteoporosis or postmenopausal osteoporosis. Osteoporosis is characterized by reduced bone mass, disruption of bone microarchitecture without alteration in the composition of bone. Osteoporotic bones are more at risk of fracture. A chromosomal aberration involving COL1A1 is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGF. Belongs to the fibrillar collagen family. Protein type: Extracellular matrix; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 17q21.33. Cellular Component: collagen type I trimer; endoplasmic reticulum lumen; extracellular matrix; extracellular region; extracellular space; Golgi apparatus; secretory granule. Molecular Function: extracellular matrix structural constituent; identical protein binding; metal ion binding; platelet-derived growth factor binding; protease binding; protein binding. Biological Process: blood coagulation; blood vessel development; cellular response to epidermal growth factor stimulus; cellular response to fibroblast growth factor stimulus; cellular response to fluoride; cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; cellular response to vitamin E; collagen biosynthetic process; collagen catabolic process; collagen fibril organization; collagen-activated tyrosine kinase receptor signaling pathway; embryonic skeletal system development; endochondral ossification; extracellular matrix organization; intramembranous ossification; leukocyte migration; negative regulation of cell-substrate adhesion; osteoblast differentiation; platelet activation; positive regulation of canonical Wnt signaling pathway; positive regulation of cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of transcription, DNA-templated; protein localization to nucleus; protein transport; regulation of immune response; response to cAMP; response to corticosteroid stimulus; response to drug; response to estradiol; response to hydrogen peroxide; response to hyperoxia; response to peptide hormone; sensory perception of sound; skeletal system development; skin morphogenesis; tooth eruption; tooth mineralization; visual perception. Disease: Caffey Disease; Ehlers-danlos Syndrome, Type I; Ehlers-danlos Syndrome, Type Vii, Autosomal Dominant; Osteogenesis Imperfecta, Type I; Osteogenesis Imperfecta, Type Ii; Osteogenesis Imperfecta, Type Iii; Osteogenesis Imperfecta, Type Iv; Osteoporosis
尺寸1 :
0.01毫克
价格1 :
125美元
尺寸2 :
0.02毫克
价格2 :
145
size3 :
0.05毫克
价格3 :
205
size4 :
0.1毫克
price4 :
270
size5 :
0.2毫克
price5 :
420
size6 :
1毫克
price6 :
995
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。