产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
多克隆抗体转谷氨酰胺酶2, 组织(TGM2)
目录 :
MBS2005631
规格 :
0.01毫克
价格 :
105美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS2005631 图像 1
Western Blot: Sample: Mouse Placenta lysate; Primary Ab: 1ug/ml Rabbit Anti-Human TGM2 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
图像 2 :
MyBioSource MBS2005631 图像 2
Western Blot: Sample: Recombinant protein.
图像 3 :
MyBioSource MBS2005631 图像 3
DAB staining on fromalin fixed paraffin-embedded Liver tissue)
产品信息
目录号 :
MBS2005631
产品类型 :
抗体
产品全称 :
多克隆抗体转谷氨酰胺酶2, 组织(TGM2)
产品简称 :
[转谷氨酰胺酶2, 组织(TGM2)]
其他名称 :
[protein-glutamine gamma-glutamyltransferase 2 isoform a; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine gamma-glutamyltransferase 2; transglutaminase 2; Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2]
产品基因名称 :
[TGM2]
其他基因名称 :
[TGM2;TGM2;TGC;TG(C);TG(C);TGC;TGase C;TGase H;TGase-2]
克隆性 :
多克隆
宿主 :
序列长度 :
687
纯度 :
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
形式 :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
浓度 :
1毫克/毫升
储存稳定性 :
Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫细胞化学(免疫细胞化学), 免疫沉淀(免疫沉淀)
应用笔记 :
Western blotting: 0.5-2 ug/mL;1:500-2000. Immunohistochemistry: 5-20 ug/mL;1:50-200. Immunocytochemistry: 5-20 ug/mL;1:50-200. Optimal working dilutions must be determined by end user.
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫印迹(免疫印迹)
image3头 :
免疫组化(免疫组化)
image4头 :
基因敲除验证
image4描述 :
Knockout Validation: Lane 1: Wild-type Hela cell lysate; Lane 2: TGM2 knockout Hela cell lysate; Predicted MW: 77kd Observed MW: 77kd Primary Ab: 1ug/ml Rabbit Anti-Human TGM2 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047)
其它信息1 :
Organism Species: Homo sapiens (Human). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant TGM2 (Met1~Ala687 (Accession # P21980)) expressed in E.coli
其他信息2 :
Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2059642
产品种类 :
Knock-Out Validation Antibody
NCBI GI登录号 :
1020158911
NCBI登录号 :
NP_001310245.1
NCBI基因登录号 :
NM_001323316.1
UniProt数据库登录号 :
P21980
NCBI信号通路 :
Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Thromboxane A2 Receptor Signaling Pathway (138060)
NCBI总结 :
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
TGM2: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described. Protein type: EC 2.3.2.13; Transferase. Chromosomal Location of Human Ortholog: 20q11.23. Cellular Component: cytosol; endoplasmic reticulum; extracellular exosome; extracellular matrix; focal adhesion; intrinsic component of plasma membrane; mitochondrion. Molecular Function: GTP binding; metal ion binding; protein binding; protein domain specific binding; protein-glutamine gamma-glutamyltransferase activity. Biological Process: apoptotic cell clearance; blood vessel remodeling; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; negative regulation of endoplasmic reticulum calcium ion concentration; positive regulation of apoptosis; positive regulation of cell adhesion; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of inflammatory response; positive regulation of mitochondrial calcium ion concentration; positive regulation of smooth muscle cell proliferation; protein homooligomerization
尺寸1 :
0.01毫克
价格1 :
105美元
尺寸2 :
0.02毫克
价格2 :
125
size3 :
0.05毫克
价格3 :
170
size4 :
0.1毫克
price4 :
220
size5 :
0.2毫克
price5 :
320
size6 :
1毫克
price6 :
760
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。