抗体

Polyclonal Antibody to Neurofilament, Light Polypeptide (NEFL)

MBS2006101

0.01毫克

110美元

多克隆

兔

未共轭

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀

抗体

Polyclonal Antibody to Neurofilament, Light Polypeptide (NEFL)

[Neurofilament, Light Polypeptide (NEFL)]

[neurofilament light polypeptide; Neurofilament light polypeptide; neurofilament light polypeptide; neurofilament light; 68 kDa neurofilament protein; Neurofilament triplet L protein]

[NEFL]

[NEFL;NEFL;NFL;NF-L;NF68;CMT1F;CMT2E;PPP1R110;NF68;NFL;NF-L]

多克隆

兔

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

0.69毫克/毫升

Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

免疫细胞化学(免疫细胞化学), 免疫组化(免疫组化), 免疫印迹(免疫印迹), 免疫沉淀(免疫沉淀)

Western blotting: 0.5-2 ug/mL. Immunohistochemistry: 5-20 ug/mL . Immunocytochemistry: 5-20 ug/mL. Optimal working dilutions must be determined by end user

免疫印迹(免疫印迹)

免疫印迹(免疫印迹)

免疫印迹(免疫印迹)

Organism Species: Homo sapiens (Human). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant NEFL (Lys281~Glu396) expressed in E.coli

105990539

NP_006149.2

NM_006158.4

P07196

Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); CREB Phosphorylation Through The Activation Of CaMKII Pathway (161040); CREB Phosphorylation Through The Activation Of Ras Pathway (161036); Neuronal System Pathway (106513); Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway (106534); Post NMDA Receptor Activation Events Pathway (161035); Ras Activation Uopn Ca2+ Infux Through NMDA Receptor Pathway (161037)

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]

NFL: one of the three (L, M, and H) intermediate filament proteins that form neurofilaments. Neurofilaments are involved in the maintenance of neuronal caliber. NF-L is the most abundant of the three neurofilament proteins. Defects cause Charcot-Marie-Tooth disease type 1F (CMT1F). Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 8p21.2. Cellular Component: axon; axon cytoplasm; cytoplasm; cytosol; growth cone; myelin sheath; neurofilament; TSC1-TSC2 complex. Molecular Function: identical protein binding; phospholipase binding; protein binding; protein binding, bridging; protein C-terminus binding; protein domain specific binding; protein heterodimerization activity; Ras guanyl-nucleotide exchange factor activity; structural constituent of cytoskeleton. Biological Process: anterograde axon cargo transport; axon regeneration in the peripheral nervous system; axonal transport of mitochondrion; cerebral cortex development; hippocampus development; intermediate filament organization; intermediate filament polymerization and/or depolymerization; locomotion; MAPK cascade; microtubule cytoskeleton organization; negative regulation of neuron apoptosis; neurofilament bundle assembly; neuromuscular process controlling balance; neuron projection morphogenesis; positive regulation of axonogenesis; protein polymerization; regulation of axon diameter; regulation of molecular function; response to acrylamide; response to corticosterone stimulus; response to peptide hormone; response to sodium arsenite; response to toxin; retrograde axon cargo transport; spinal cord development. Disease: Charcot-marie-tooth Disease, Axonal, Type 2e; Charcot-marie-tooth Disease, Demyelinating, Type 1f

0.01毫克

110美元

0.02毫克

130

0.05毫克

175

0.1毫克

225

0.2毫克

340

1毫克

800