抗体

Polyclonal Antibody to Inducible T-Cell Co Stimulator (ICOS)

MBS2007085

0.01毫克

130美元

多克隆

兔

未共轭

人类, 小鼠

免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片

抗体

Polyclonal Antibody to Inducible T-Cell Co Stimulator (ICOS)

Inducible T-Cell Co Stimulator (ICOS)

inducible T-cell co-stimulator; Inducible T-cell costimulator; inducible T-cell costimulator; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; inducible T-cell co-stimulator; Activation-inducible lymphocyte immunomediatory molecule

ICOS

ICOS;ICOS;AILIM;CD278;CVID1;AILIM

ICOS_HUMAN

多克隆

IgG

兔

小鼠

The antibody is a rabbit polyclonal antibody raised against ICOS. It has been selected for its ability to recognize ICOS in immunohistochemical staining andwestern blotting.

Antigen-specific Affinity Chromatography.

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

200微克/毫升

Storage: Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.

免疫印迹;免疫细胞化学;免疫组化-P;免疫组化-F;酶联免疫吸附测定;免疫沉淀;IF;FCM

Western blotting: 0.5-2ug/ml. Immunocytochemistry in formalin fixed cells: 5-20ug/ml. Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml. Immunohistochemistry in paraffin section: 5-20ug/ml. Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml. Optimal working dilutions must be determined by end user.

Source: Polyclonal antibody preparation. Traits: Liquid

Immunogen: Recombinant ICOS (Asn35~Ile131) expressed in E.coli.

9968296

CAC06612.1

Q9Y6W8

Adaptive Immune System Pathway (366160); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Costimulation By The CD28 Family Pathway (119552); Immune System Pathway (106386); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670); Primary Immunodeficiency Pathway (83125); Primary Immunodeficiency Pathway (537); T Cell Receptor Signaling Pathway (83080)

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]

ICOS: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. Defects in ICOS are the cause of immunodeficiency common variable type 1 (CVID1). CVID1 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be lo. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 2q33. Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; external side of plasma membrane. Biological Process: cell-cell adhesion; T cell tolerance induction; T cell costimulation; immune response. Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 1

0.01毫克

130美元

0.05毫克

225

0.1毫克

290