产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
生物素链接抗体肿瘤坏死因子乙(TNFb)
目录 :
MBS2008680
规格 :
0.1毫克
价格 :
230美元
克隆性 :
多克隆
宿主 :
共轭标签 :
生物素
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
产品信息
目录号 :
MBS2008680
产品类型 :
抗体
产品全称 :
生物素链接抗体肿瘤坏死因子乙(TNFb)
产品简称 :
[肿瘤坏死因子乙(TNFb)]
其他名称 :
[tumor necrosis factor-beta; Lymphotoxin-alpha; lymphotoxin-alpha; LT-alpha; TNF-beta; TNF superfamily, member 1; tumor necrosis factor beta; tumor necrosis factor ligand superfamily member 1; lymphotoxin alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1]
产品基因名称 :
[TNFb]
其他基因名称 :
[LTA;LTA;LT;TNFB;TNFSF1;TNFB;TNFSF1;LT甲]
UniProt数据库进入名 :
TNFB_HUMAN
克隆性 :
多克隆
宿主 :
反应物种 :
小鼠
纯度 :
Antigen-specific Affinity Chromatography
形式 :
Form & Buffer: Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol
浓度 :
0.21毫克/毫升
储存稳定性 :
Storage : Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months. Stability Test : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫细胞化学(免疫细胞化学), 免疫沉淀(免疫沉淀)
应用笔记 :
Western blotting: 0.5-2ug/mL. Immunohistochemistry: 5-20ug/mL. Immunocytochemistry: 5-20ug/mL. Optimal working dilutions must be determined by end user.
其它信息1 :
Source: Antibody labeling. Label: Biotin. Traits: Liquid. Immunogen: Recombinant TNFb (Pro49~Leu202) expressed in E.coli.
产品种类 :
生物素抗体
NCBI GI登录号 :
339743
NCBI登录号 :
AAB59455.1
UniProt数据库登录号 :
P01374
NCBI信号通路 :
Apoptosis Pathway (198797); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Herpes Simplex Infection Pathway (377873); Herpes Simplex Infection Pathway (377865); IL2 Signaling Events Mediated By STAT5 Pathway (137988); IL4-mediated Signaling Events Pathway (137933); NF-kappa B Signaling Pathway (634527)
NCBI总结 :
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
UniProt数据库总结 :
LTA: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS). PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). Belongs to the tumor necrosis factor family. Protein type: Secreted; Secreted, signal peptide; Cytokine; Apoptosis. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: extracellular space; membrane. Molecular Function: cytokine activity; tumor necrosis factor receptor binding; receptor binding. Biological Process: response to drug; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of apoptosis; apoptosis; response to lipopolysaccharide; signal transduction; lymph node development; humoral immune response; defense response to Gram-positive bacterium; positive regulation of interferon-gamma production; cell-cell signaling; negative regulation of fibroblast proliferation; response to hypoxia; positive regulation of chronic inflammatory response to antigenic stimulus; response to nutrient. Disease: Psoriatic Arthritis, Susceptibility To; Myocardial Infarction, Susceptibility To; Leprosy, Susceptibility To, 4
尺寸1 :
0.1毫克
价格1 :
230美元
尺寸2 :
0.2毫克
价格2 :
345
size3 :
1毫克
价格3 :
815
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。