产品简要
公司名称 :
MyBioSource
产品类型 :
蛋白
产品名称 :
Recombinant Neurofilament, Light Polypeptide (NEFL)
目录 :
MBS2009843
规格 :
0.01毫克
价格 :
135美元
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS2009843 图像 1
产品信息
目录号 :
MBS2009843
产品类型 :
重组蛋白
产品全称 :
Recombinant Neurofilament, Light Polypeptide (NEFL)
产品简称 :
[Neurofilament, Light Polypeptide (NEFL)]
其他名称 :
[neurofilament light polypeptide; Neurofilament light polypeptide; neurofilament light polypeptide; neurofilament subunit NF-L; neurofilament triplet L protein; neurofilament protein, light chain; neurofilament, light polypeptide 68kDa; light molecular weight neurofilament protein; neurofilament, light polypeptide; 68 kDa neurofilament protein; Neurofilament triplet L protein]
产品基因名称 :
[NEFL]
其他基因名称 :
[NEFL;NEFL;NFL;NF-L;NF68;CMT1F;CMT2E;NF68;NFL;NF-L]
UniProt数据库进入名 :
NFL_HUMAN
宿主 :
大肠杆菌
纯度 :
> 97%
形式 :
PBS, pH7.4, 含0.01% SKL, 1mM DTT, 5% 海藻糖和ProClin防腐剂300
浓度 :
Original Concentration: 200ug/mL
储存稳定性 :
Storage: Avoid repeated freeze/thaw cycles. Store at 2-8ºC for one month. Aliquot and store at -80ºC for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
检测过的应用 :
Positive Control; Immunogen; SDS-PAGE; Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.)
image1头 :
SDS-Page
image2头 :
序列
其它信息1 :
Organism Species: Homo sapiens (Human). Source: Prokaryotic expression. Residues: Lys281~Glu396. Tags: N-terminal His Tag
其他信息2 :
Predicted isoelectric point: 5.9. Usage: Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex. Traits: Freeze-dried powder
NCBI GI登录号 :
105990539
NCBI登录号 :
NP_006149.2
NCBI基因登录号 :
NM_006158.4
UniProt数据库登录号 :
P07196
NCBI分子量 :
Predicted Molecular Mass: 14.5kDa. Accurate Molecular Mass: 15kDa as determined by SDS-PAGE reducing conditions.
NCBI信号通路 :
Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); CREB Phosphorylation Through The Activation Of CaMKII Pathway (161040); CREB Phosphorylation Through The Activation Of Ras Pathway (161036); Neuronal System Pathway (106513); Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway (106534); Post NMDA Receptor Activation Events Pathway (161035); Ras Activation Uopn Ca2+ Infux Through NMDA Receptor Pathway (161037)
NCBI总结 :
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]
UniProt数据库总结 :
NFL: one of the three (L, M, and H) intermediate filament proteins that form neurofilaments. Neurofilaments are involved in the maintenance of neuronal caliber. NF-L is the most abundant of the three neurofilament proteins. Defects cause Charcot-Marie-Tooth disease type 1F (CMT1F). Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 8p21. Cellular Component: TSC1-TSC2 complex; growth cone; axon; cytoplasm; neurofilament; cytosol. Molecular Function: protein C-terminus binding; protein binding, bridging; identical protein binding; protein domain specific binding; protein binding; phospholipase binding; structural constituent of cytoskeleton. Biological Process: protein polymerization; response to peptide hormone stimulus; neurofilament bundle assembly; response to toxin; intermediate filament organization; microtubule cytoskeleton organization and biogenesis; axon regeneration in the peripheral nervous system; retrograde axon cargo transport; synaptic transmission; axon transport of mitochondrion; regulation of axon diameter; positive regulation of axonogenesis; negative regulation of neuron apoptosis; locomotion; neuromuscular process controlling balance; anterograde axon cargo transport; neurite morphogenesis; response to corticosterone stimulus. Disease: Charcot-marie-tooth Disease, Demyelinating, Type 1f; Charcot-marie-tooth Disease, Axonal, Type 2e
尺寸1 :
0.01毫克
价格1 :
135美元
尺寸2 :
0.05毫克
价格2 :
245
size3 :
0.1毫克
价格3 :
365
size4 :
0.2毫克
price4 :
450
size5 :
0.5毫克
price5 :
870
size6 :
1毫克
price6 :
1280
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。