抗体

异硫氰酸荧光素链接抗体糖蛋白130(gp130)

MBS2013571

0.1毫克

385美元

多克隆

兔

异硫氰酸荧光素

人类, 小鼠

免疫印迹, 免疫组化, 免疫细胞化学

抗体

异硫氰酸荧光素链接抗体糖蛋白130(gp130)

糖蛋白130(gp130)

glycoprotein 130; Interleukin-6 receptor subunit beta; interleukin-6 receptor subunit beta; IL-6RB; IL-6R-beta; IL-6R subunit beta; membrane glycoprotein 130; IL-6 receptor subunit beta; interleukin-6 signal transducer; oncostatin-M receptor subunit alpha; interleukin 6 signal transducer; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha

gp130

Il6st;Il6st;CD130;gp130;AA389424;BB405851;D13Ertd699e;5133400A03Rik;IL-6受体亚单位乙;IL-6R亚单位乙;IL-6R;IL-6RB;gp130

IL6RB_MOUSE

多克隆

IgG

兔

人类

917

The antibody is a rabbit polyclonal antibody raised against gp130. It has been selected for its ability to recognize gp130 in immunohistochemical staining and western blotting.

亲和色谱

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

100微克/毫升

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles. Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.

免疫组化(免疫组化), 免疫细胞化学(免疫细胞化学), 免疫荧光(IF), 免疫印迹(免疫印迹)

Western blotting: 1:50-400. Immunocytochemistry in formalin fixed cells: 1:50-500. Immunohistochemistry in formalin fixed frozen section: 1:50-500. Immunohistochemistry in paraffin section: 1:10-100. Enzyme-linked Immunosorbent Assay: 1:100-200. Optimal working dilutions must be determined by end user.

异硫氰酸荧光素抗体

193592

AAA37723.1

Q00560

102,451 Da

Adipogenesis Pathway (198299); Androgen Receptor Signaling Pathway (198319); Cytokine Signaling In Immune System Pathway (926145); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); ESC Pluripotency Pathways (198374); IL-6 Signaling Pathway (198302); Immune System Pathway (926012); Interleukin-6 Signaling Pathway (926160); Jak-STAT Signaling Pathway (83274)

gp130: gp130 is a ubiquitously expressed type I cytokine family receptor. The receptor systems for IL6, LIF, OSM, CNTF, IL11 AND CT1 utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not directly bind IL6. May have a role in embryonic development. Contains 5 fibronectin type III domains and 1 immunoglobulin-like C2-type domain. Two alternatively spliced isoforms have been described. Protein type: Membrane protein, integral; Receptor, cytokine. Cellular Component: extracellular space; cell soma; membrane; oncostatin-M receptor complex; dendrite; integral to membrane; interleukin-6 receptor complex; cytosol; external side of plasma membrane. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-11 binding; protein binding; interleukin-6 binding; interleukin-6 receptor binding; leukemia inhibitory factor receptor activity; oncostatin-M receptor activity; protein heterodimerization activity; growth factor binding; ciliary neurotrophic factor receptor activity; interleukin-6 receptor activity; ciliary neurotrophic factor receptor binding; interleukin-11 receptor activity. Biological Process: glycogen metabolic process; cytokine and chemokine mediated signaling pathway; leukemia inhibitory factor signaling pathway; positive regulation of smooth muscle cell migration; signal transduction; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of osteoblast differentiation; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of Notch signaling pathway; response to cytokine stimulus; reduction of cytosolic calcium ion concentration; positive regulation of cell proliferation; positive regulation of T cell proliferation; triacylglycerol mobilization; positive regulation of astrocyte differentiation

0.1毫克

385美元