抗体

Polyclonal Antibody to Granulin (GRN)

MBS2015017

0.01毫克

110美元

多克隆

兔

未共轭

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀

抗体

Polyclonal Antibody to Granulin (GRN)

[Granulin (GRN)]

[granulins; Granulins; granulins; granulin precursor; Proepithelin; PEPI]

[GRN]

[GRN;GRN;GEP;GP88;PEPI;PGRN;CLN11;PCDGF;PEPI;GP88;糖蛋白88]

多克隆

兔

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

0.58毫克/毫升

Storage: Avoid repeated freeze/thaw cycles. Store at 4ºC for frequent use. Aliquot and store at -20ºC for 24 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Western Blot (WB), Immunohistichemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Western blotting: 0.5-2ug/mL. Immunohistochemistry: 5-20ug/mL. Immunocytochemistry: 5-20ug/mL. Optimal working dilutions must be determined by end user.

免疫印迹(免疫印迹)

免疫印迹(免疫印迹)

免疫组化(免疫组化)

Organism Species: Homo sapiens (Human). Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant GRN (Lys361~Arg585) expressed in E.coli

Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2066343

Knock-Out Validation Antibody

4504151

NP_002078.1

NM_002087.3

P28799

Integrated Breast Cancer Pathway (219801)

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]

GRN: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD); also known as tau- negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease. Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11). A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. Belongs to the granulin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 17q21.31. Cellular Component: endoplasmic reticulum; endosome; extracellular region; lysosome. Molecular Function: cytokine activity; growth factor activity; protein binding; RNA binding. Biological Process: neutrophil degranulation; signal transduction. Disease: Ceroid Lipofuscinosis, Neuronal, 11; Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related

0.01毫克

110美元

0.02毫克

130

0.05毫克

175

0.1毫克

225

0.2毫克

340

1毫克

800