抗体

FITC-linked Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A)

MBS2017626

0.1毫克

255美元

多克隆

兔

异硫氰酸荧光素

人类, 小鼠

免疫印迹, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片

抗体

FITC-linked Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A)

[Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A)]

[tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor superfamily member 1A; tumor necrosis factor receptor superfamily member 1A; TNF-R1; TNF-RI; TNFR-I; tumor necrosis factor-alpha receptor; tumor necrosis factor receptor type 1; tumor necrosis factor binding protein 1; tumor necrosis factor receptor 1A isoform beta; tumor necrosis factor receptor superfamily, member 1A; Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60]

[肿瘤坏死因子受体超家族成员1A]

[肿瘤坏死因子受体超家族成员1A;肿瘤坏死因子受体超家族成员1A;FPF;MS5;p55;p60;TBP1;肿瘤坏死因子-R;TNFAR;TNFR1;p55-R;CD120a;TNFR55;TNFR60;肿瘤坏死因子-R;肿瘤坏死因子-R55;TNFR1-d2;TNFAR;TNFR1;肿瘤坏死因子-R1;肿瘤坏死因子-RI;TNFR-I;TBPI]

TNR1A_HUMAN

多克隆

IgG

兔

小鼠

455

The antibody is a rabbit polyclonal antibody raised against TNFRSF1A. It has been selected for its ability to recognize TNFRSF1A in immunohistochemical staining and western blotting.

亲和色谱

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

200微克/毫升

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

免疫组化冷冻/石蜡(免疫组化-F/P), 免疫细胞化学(免疫细胞化学), 免疫荧光(IF), 免疫印迹(免疫印迹)

Western blotting: 1:50-400. Immunocytochemistry in formalin fixed cells: 1:50-500. Immunohistochemistry in formalin fixed frozen section: 1:50-500. Immunohistochemistry in paraffin section: 1:10-100. Enzyme-linked Immunosorbent Assay: 1:100-200. Optimal working dilutions must be determined by end user.

免疫印迹

UOM: 100ug. Immunogen: TNFRSF1A, Mouse. Immunogen: Recombinant TNFRSF1A (Arg239~Cys433) with N-terminal His-Tag expressed in E.coli. Accession No.: RPB499Mu01

QUALITY CONTROL: Content: The quality control contains recombinant TNFRSF1A (Arg239~Cys433) disposed in loading buffer. Usage: 10uL per well when 3,3'-Diaminobenzidine(DAB) as the substrate. 5uL per well when used in enhanced chemilumescent (ECL). Note: The quality control is specifically manufactured as the positive control. Not used for other purposes. Loading Buffer: 100mM Tris(pH8.8), 2% SDS, 200mM NaCl, 50% glycerol, BPB 0.01%, NaN3 0.02%.

异硫氰酸荧光素抗体

4507575

NP_001056.1

NM_001065.3

P19438

Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Apoptosis Pathway (198797); Apoptosis Pathway (83060)

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]

TNF-R1: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. Interacts with human cytomegalovirus/HHV-5 protein UL138. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 12p13.2. Cellular Component: extracellular space; cell surface; mitochondrion; integral to plasma membrane; extracellular region; cytosol; lipid raft; Golgi membrane; axon; plasma membrane; synapse; nucleus; receptor complex. Molecular Function: protein binding; tumor necrosis factor receptor activity; protease binding; protein complex binding; tumor necrosis factor binding. Biological Process: response to alkaloid; viral reproduction; protein heterooligomerization; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway; positive regulation of neuron apoptosis; response to wounding; negative regulation of interleukin-6 production; tetrapyrrole metabolic process; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein import into nucleus, translocation; cytokine and chemokine mediated signaling pathway; response to amino acid stimulus; positive regulation of tumor necrosis factor production; prostaglandin metabolic process; positive regulation of angiogenesis; positive regulation of tyrosine phosphorylation of Stat1 protein; response to ethanol; DNA damage response, signal transduction resulting in induction of apoptosis; induction of apoptosis via death domain receptors; negative regulation of inflammatory response; defense response to bacterium; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; positive regulation of inflammatory response; negative regulation of apoptosis. Disease: Multiple Sclerosis, Susceptibility To, 5; Periodic Fever, Familial, Autosomal Dominant

0.1毫克

255美元

0.2毫克

390

1毫克

935