产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
单克隆抗体神经纤毛蛋白1(NRP1)
目录 :
MBS2025850
规格 :
0.01毫克
价格 :
100美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
[4#]
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS2025850 图像 1
Western Blot: Sample: Recombinant NRP1, Human.
产品信息
目录号 :
MBS2025850
产品类型 :
抗体
产品全称 :
单克隆抗体神经纤毛蛋白1(NRP1)
产品简称 :
[神经纤毛蛋白1]
其他名称 :
[neuropilin-1 isoform b; Neuropilin-1; neuropilin-1; neuropilin 1; Vascular endothelial cell growth factor 165 receptor; CD_antigen: CD304]
产品基因名称 :
[NRP1]
其他基因名称 :
[NRP1;NRP1;NP1;NRP;BDCA4;CD304;VEGF165R;NRP;VEGF165R]
克隆性 :
单克隆
抗体亚型 :
IgG2b Kappa
克隆 :
[4#]
宿主 :
小鼠
反应物种 :
人类
特异性 :
The antibody is a mouse monoclonal antibody raised against NRP1. It has beenselected for its ability to recognize NRP1 in immunohistochemical staining andwestern blotting.
纯度 :
蛋白质A/G亲和色谱
形式 :
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
浓度 :
500微克/毫升
储存稳定性 :
Storage: Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.
检测过的应用 :
免疫印迹;免疫细胞化学;免疫组化-P;免疫组化-F;酶联免疫吸附测定;免疫沉淀;IF;FCM
应用笔记 :
Western blotting: 0.5-5ug/ml. Immunocytochemistry in formalin fixed cells: 5-30ug/ml. Immunohistochemistry in formalin fixed frozen section: 5-30ug/ml. Immunohistochemistry in paraffin section: 5-30ug/ml. Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml. Optimal working dilutions must be determined by end user.
image1头 :
免疫印迹(免疫印迹)
其它信息1 :
Source: Monoclonal antibody preparation. Traits: Liquid
其他信息2 :
Immunogen: Recombinant NRP1 (Tyr646~Asp814) expressed in E.coli. Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2046121
NCBI GI登录号 :
66912178
NCBI登录号 :
NP_001019799.1
NCBI基因登录号 :
NM_001024628.2
UniProt数据库登录号 :
O14786
NCBI分子量 :
68,376 Da
NCBI信号通路 :
Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); CHL1 Interactions Pathway (161007); CRMPs In Sema3A Signaling Pathway (119525); Developmental Biology Pathway (477129); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); L1CAM Interactions Pathway (161003); Neurophilin Interactions With VEGF And VEGFR Pathway (106509)
NCBI总结 :
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
UniProt数据库总结 :
NRP1: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1. The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. Belongs to the neuropilin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 10p11.22. Cellular Component: axon; cell soma; cell surface; cytoplasmic vesicle; cytosol; early endosome; extracellular space; focal adhesion; growth cone; integral component of membrane; neurofilament; neuron projection; plasma membrane; receptor complex. Molecular Function: coreceptor activity; cytokine binding; growth factor binding; GTPase activator activity; heparin binding; metal ion binding; protein binding; semaphorin receptor activity; vascular endothelial growth factor binding; vascular endothelial growth factor-activated receptor activity. Biological Process: actin cytoskeleton reorganization; angiogenesis; artery morphogenesis; axon extension involved in axon guidance; axon guidance; axonal fasciculation; branching involved in blood vessel morphogenesis; branchiomotor neuron axon guidance; cell migration during sprouting angiogenesis; cell-cell signaling; commissural neuron axon guidance; dendrite arborization; dendrite development; dorsal root ganglion morphogenesis; endothelial cell migration; facial nerve structural organization; gonadotrophin-releasing hormone neuronal migration to the hypothalamus; hepatocyte growth factor receptor signaling pathway; integrin-mediated signaling pathway; negative regulation of axon extension involved in axon guidance; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of neuron apoptosis; nerve development; neural crest cell migration involved in autonomic nervous system development; neuron migration; neuropilin signaling pathway; organ morphogenesis; otic placode development; outflow tract septum morphogenesis; platelet-derived growth factor receptor signaling pathway; positive chemotaxis; positive regulation of actin cytoskeleton reorganization; positive regulation of axon extension involved in axon guidance; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of filopodium formation; positive regulation of focal adhesion assembly; positive regulation of GTPase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphorylation; positive regulation of retinal ganglion cell axon guidance; positive regulation of smooth muscle cell migration; positive regulation of stress fiber formation; positive regulation of substrate adhesion-dependent cell spreading; regulation of Cdc42 protein signal transduction; regulation of retinal ganglion cell axon guidance; response to wounding; retinal ganglion cell axon guidance; semaphorin-plexin signaling pathway; semaphorin-plexin signaling pathway involved in axon guidance; semaphorin-plexin signaling pathway involved in neuron projection guidance; signal transduction; sprouting angiogenesis; substrate-dependent cell migration, cell extension; toxin transport; trigeminal nerve structural organization; vascular endothelial growth factor receptor signaling pathway; VEGF-activated neuropilin signaling pathway; ventral trunk neural crest cell migration; vestibulocochlear nerve structural organization
尺寸1 :
0.01毫克
价格1 :
100美元
尺寸2 :
0.02毫克
价格2 :
110
size3 :
0.05毫克
价格3 :
140
size4 :
0.1毫克
price4 :
170
size5 :
0.2毫克
price5 :
220
size6 :
1毫克
price6 :
495
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。