产品简要
公司名称 :
MyBioSource
产品类型 :
蛋白
产品名称 :
干扰素丙, 人类, 重组, 大肠杆菌
目录 :
MBS203080
规格 :
0.1毫克
价格 :
255美元
更多信息或购买 :
产品信息
目录号 :
MBS203080
产品类型 :
重组蛋白
产品全称 :
干扰素丙, 人类, 重组, 大肠杆菌
产品简称 :
干扰素丙
产品名称同义词 :
Ifng; Interferon-g; IFN-gamma; Interferon gamma; IFNG; IFG; IFI; IFN gamma; IFN immune; Immune interferon; Interferon gamma precursor; Macrophage activating factor; MAF; T Cell interferon; Type II Interferon
其他名称 :
interferon gamma; Interferon gamma; interferon gamma; IFN-gamma; immune interferon; interferon, gamma; Immune interferon
其他基因名称 :
IFNG;IFNG;IFG;IFI;IFN丙
UniProt数据库进入名 :
IFNG_HUMAN
序列长度 :
166
序列 :
MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFRGR RASQ
纯度 :
> 95% by SDS - PAGE
形式 :
液体。 在磷酸盐缓冲液(PBS), pH7.4
浓度 :
1毫克/毫升(由布拉德福德Bradford检测确定)
储存稳定性 :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
检测过的应用 :
十二烷基磺酸钠-PAGE
其它信息1 :
Antigen Species: Human
其他信息2 :
Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)
产品种类 :
激素&细胞因子
产品描述 :
Nature human interferon-gamma is composed of 143amino acid residues without cysteine residues and is glycosylated. Recombinant human interferon-gamma was expressed in E.coli and purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. Additional amino acid(Methionine) is attached at N-terminus.
产品引用 :
Sen GC, Lengyel P (1992) J. Biol. Chem. 267(8):5017-5020. Tsutomu Arakawa, Yeuh-Rong Hsu (1987) Biochemistry. 26:5428-5432. Ernst Rinderknecht, et al (1984) J. Biol. Chem. 259(11):6790-6797.
NCBI GI登录号 :
56786138
NCBI登录号 :
NP_000610
NCBI基因登录号 :
NM_000619.2
NCBI分子量 :
16.9kDa (144aa), confirmed by MALDI-TOF.
NCBI信号通路 :
ATF-2 Transcription Factor Network Pathway (138006); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Allograft Rejection Pathway (920963); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485)
NCBI总结 :
This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009]
UniProt数据库总结 :
IFNG: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. Homodimer. Released primarily from activated T lymphocytes. Belongs to the type II (or gamma) interferon family. Protein type: Secreted, signal peptide; Cytokine; Membrane protein, integral; Secreted. Chromosomal Location of Human Ortholog: 12q14. Cellular Component: extracellular space; extracellular region; external side of plasma membrane. Molecular Function: interferon-gamma receptor binding; cytokine activity. Biological Process: positive regulation of isotype switching to IgG isotypes; positive regulation of nitric oxide biosynthetic process; positive regulation of osteoclast differentiation; negative regulation of smooth muscle cell proliferation; positive regulation of interleukin-23 production; positive regulation of interleukin-12 production; apoptosis; positive regulation of interleukin-6 biosynthetic process; negative regulation of epithelial cell differentiation; positive regulation of interleukin-1 beta secretion; sensory perception of mechanical stimulus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of killing of cells of another organism; positive regulation of membrane protein ectodomain proteolysis; cell surface receptor linked signal transduction; positive regulation of MHC class II biosynthetic process; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of T cell proliferation; cell cycle arrest; defense response to virus; regulation of the force of heart contraction; positive regulation of peptidyl-serine phosphorylation of STAT protein; response to drug; positive regulation of synaptic transmission, cholinergic; neutrophil chemotaxis; adaptive immune response; negative regulation of myelination; CD8-positive, alpha-beta T cell differentiation during immune response; unfolded protein response; response to virus; cytokine and chemokine mediated signaling pathway; positive regulation of tumor necrosis factor production; defense response to protozoan; humoral immune response; antigen processing and presentation; positive regulation of tyrosine phosphorylation of Stat1 protein; negative regulation of interleukin-17 production; positive regulation of interleukin-12 biosynthetic process; positive regulation of chemokine biosynthetic process; protein import into nucleus, translocation; defense response to bacterium; neutrophil apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; cell motility; regulation of insulin secretion. Disease: Hepatitis C Virus, Susceptibility To; Aplastic Anemia; Mycobacterium Tuberculosis, Susceptibility To; Tuberous Sclerosis 2; Human Immunodeficiency Virus Type 1, Susceptibility To
尺寸1 :
0.1毫克
价格1 :
255美元
尺寸2 :
0.5毫克
价格2 :
535
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。