产品简要
公司名称 :
MyBioSource
产品类型 :
蛋白
产品名称 :
CCL2/MCP-1, 24-99aa, 人类, 多聚组氨酸标签, 重组, 大肠杆菌
目录 :
MBS203231
规格 :
0.1毫克
价格 :
255美元
更多信息或购买 :
产品信息
目录号 :
MBS203231
产品类型 :
重组蛋白
产品全称 :
CCL2/MCP-1, 24-99aa, 人类, 多聚组氨酸标签, 重组, 大肠杆菌
产品简称 :
CCL2/MCP-1
产品名称同义词 :
MCAF; GDCF-2; HC11; SCYA2; Chemokine (C-C motif) ligand 2; CCL2; small inducible cytokine A2 (monocyte chemotactic protein 1 homologous to mouse Sig-je); MCP1; MCP-1; SMC-CF; MGC9434
其他名称 :
C-C motif chemokine 2; C-C motif chemokine 2; C-C motif chemokine 2; monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; monocyte chemotactic protein 1; monocyte secretory protein JE; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; small-inducible cytokine A2; chemokine (C-C motif) ligand 2; HC11; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte chemotactic protein 1; MCP-1; Monocyte secretory protein JE; Small-inducible cytokine A2
产品基因名称 :
CCL2/MCP-1
其他基因名称 :
CCL2;CCL2;HC11;MCAF;MCP1;MCP-1;SCYA2;GDCF-2;SMC-CF;HSMCR30;MCP1;SCYA2;MCAF;MCP-1
UniProt数据库进入名 :
CCL2_HUMAN
序列长度 :
99
序列 :
MGSSHHHHHH SSGLVPRGSH MQPDAINAPV TCCYNFTNRK ISVQRLASYR RITSSKCPKE AVIFKTIVAK EICADPKQKW VQDSMDHLDK QTQTPKT
纯度 :
> 95 % by SDS - PAGE
形式 :
液体。 在20 mM三羟甲基氨基甲烷氯化氢缓冲液(pH值8.0)含1mM DTT 20% 甘油
浓度 :
0.5毫克/毫升(由布拉德福德Bradford检测确定)
储存稳定性 :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
检测过的应用 :
十二烷基磺酸钠-PAGE
其它信息1 :
Antigen Species: Human. Tag: His-tag
其他信息2 :
Expression System: E Coli. Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)
产品种类 :
激素&细胞因子
产品描述 :
Chemokine (C-C motif) ligand 2 (CCL2) is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 (MCP-1). CCL2 recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Recombinant human CCL2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
产品引用 :
Serbina NV., et al. (2008) Annu Rev Immunol. 26:421-52. Rafei M., et al. (2009) J Immunol. 182(10):5994-6002.
NCBI GI登录号 :
4506841
NCBI登录号 :
NP_002973
NCBI基因登录号 :
NM_002982.3
NCBI分子量 :
10.9 kDa (97 aa), confirmed by MALDI-TOF.
NCBI信号通路 :
ATF4 Activates Genes Pathway 530772!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Chemokine Receptors Bind Chemokines Pathway 106359!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664
NCBI总结 :
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]
规格 :
0.1毫克
价格 :
255美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。