蛋白

GRB2, 1-217aa, 人类, 多聚组氨酸标签, 重组, 大肠杆菌

MBS203275

0.1毫克

310美元

重组蛋白

GRB2, 1-217aa, 人类, 多聚组氨酸标签, 重组, 大肠杆菌

GRB2

Growth factor receptor-bound protein 2 isoform 1; ASH; EGFRBP-GRB2; GRB3-3; Growth factor receptor-bound protein 2 isoform 1 Abundant SRC homology; Adapter protein GRB2; Ash protein; EGFRBP GRB2; Epidermal growth factor receptor binding protein; Epidermal growth factor receptor binding protein GRB2; GRB 2; GRB2 adapter protein; Grb3 3; Growth factor receptor bound protein 2; Growth factor receptor bound protein 3; HT027; MST084; MSTP084; OTTHuMP00000166096; OTTHuMP00000166097; OTTHuMP00000166098; Protein ASH; SEM5; SH2/SH3 adapter GRB2.

growth factor receptor-bound protein 2 isoform 1; Growth factor receptor-bound protein 2; growth factor receptor-bound protein 2; HT027; SH2/SH3 adapter GRB2; abundant SRC homology; epidermal growth factor receptor-binding protein GRB2; growth factor receptor-bound protein 3; protein Ash; growth factor receptor-bound protein 2; Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2

GRB2

GRB2;GRB2;ASH;Grb3-3;MST084;NCKAP2;MSTP084;EGFRBP-GRB2;ASH

GRB2_HUMAN

217

MGSSHHHHHH SSGLVPRGSH MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV

> 95% by SDS - PAGE

在20mM三羟甲基氨基甲烷氯化氢(pH8.0)缓冲液含30% 甘油

1毫克/毫升(由布拉德福德Bradford检测确定)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

十二烷基磺酸钠-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

信号转导

Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. GRB2 is widely expressed and also binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Grb2 is composed of an SH2 domain flanked on each side by an SH3 domain. Inhibition of Grb2 function impairs developmental processes in various organisms and blocks transformation and proliferation of various cell types. Recombinant human GRB2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Rudd CE., et al. (2009) Immunol Rev. 229(1):12-26. Weisswange I., et al. (2009) Nature. 458(7234):87-91.

4504111

NP_002077

NM_002086.4

27 kDa (237 aa), confirmed by MALDI-TOF.

Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adaptive Immune System Pathway (366160); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Alpha6-Beta4 Integrin Signaling Pathway (198807); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (576249); Axon Guidance Pathway (105688); B Cell Receptor Signaling Pathway (198909)

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

0.1毫克

310美元

0.5毫克

720