产品简要
公司名称 :
MyBioSource
产品类型 :
蛋白
产品名称 :
Glutaredoxin-1,1-106aa, Human, Recombinant, E Coli
目录 :
MBS203286
规格 :
0.1毫克
价格 :
255美元
更多信息或购买 :
产品信息
目录号 :
MBS203286
产品类型 :
重组蛋白
产品全称 :
Glutaredoxin-1,1-106aa, Human, Recombinant, E Coli
产品简称 :
Glutaredoxin-1
产品名称同义词 :
GLRX; GRX; GRX1; Thioltransferase-1; TTase-1; Glrx1; Glutaredoxin; Glutaredoxin1; Grx 1; MGC117407; Thioltransferase; Thioltransferase 1; Thioltransferase1; Ttase; TTase 1; TTase1.
其他名称 :
glutaredoxin-1; Glutaredoxin-1; glutaredoxin-1; TTase-1; thioltransferase-1; glutaredoxin (thioltransferase); Thioltransferase-1; TTase-1
其他基因名称 :
GLRX;GLRX;GRX;GRX1;GRX;TTase-1
UniProt数据库进入名 :
GLRX1_HUMAN
序列长度 :
106
序列 :
MAQEFVNCKI QPGKVVVFIK PTCPYCRRAQ EILSQLPIKQ GLLEFVDITA TNHTNEIQDY LQQLTGARTV PRVFIGKDCI GGCSDLVSLQ QSGELLTRLK QIGALQ
纯度 :
> 95% by SDS - PAGE
形式 :
液体。 在20 mM三羟甲基氨基甲烷氯化氢缓冲液(pH值8.0)含1 mM DTT 10% 甘油
浓度 :
1毫克/毫升(由布拉德福德Bradford检测确定)
储存稳定性 :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
检测过的应用 :
十二烷基磺酸钠-PAGE
其它信息1 :
Antigen Species: Human
其他信息2 :
Expression System: E Coli
产品种类 :
Redox Proteins
产品描述 :
Description: Glutaredoxin(GRX), also known as thioltransferase, is member of the thiol-disulfide oxidoreductase family. Glutraredoxin catalyzes the reversible reduction of protein-glutathionyl mixed disulfides to free sulfhydryl groups though a monothiol mechanism. Mammalian Glutaredoxin is known to have two isoforms, GRX1 and GRX2. GRX1 is a cytosolic protein, whereas GRX2 is localized both in the mitochondria and nucleus. Glutaredoxin-1 may be involved in a various cellular events such as signal transduction, stress response, and metabolic regulation by regulating the redox status of cellular proteins. Recombinant human Glutaredoxin1 protein was expressed in E.coli and purified by using conventional chromatography techniques.
产品引用 :
Reynaert NL., et al. (2006) Proc Natl Acad Sci u S A. 103(35):13086-91. Kanda M., et al. (2006) J Biol Chem. 281(39):28518-28.
NCBI GI登录号 :
4504025
NCBI登录号 :
NP_002055
NCBI基因登录号 :
NM_002064.2
NCBI分子量 :
11.7 kDa (106 aa), confirmed by MALDI-TOF.
NCBI信号通路 :
Metabolism Pathway (477135); Metabolism Of Nucleotides Pathway (106263); Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway (161057); Ascorbate Recycling (cytosolic) Pathway (545345); Ascorbate Recycling (cytosolic) Pathway (545621)
NCBI总结 :
This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
UniProt数据库总结 :
GLRX1: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Belongs to the glutaredoxin family. Protein type: Oxidoreductase. Chromosomal Location of Human Ortholog: 5q14. Cellular Component: mitochondrion; nucleus; cytosol. Molecular Function: electron carrier activity; protein N-terminus binding; glutathione disulfide oxidoreductase activity. Biological Process: nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; cell redox homeostasis; positive regulation of membrane potential
尺寸1 :
0.1毫克
价格1 :
255美元
尺寸2 :
0.5毫克
价格2 :
535
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。