产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
多克隆抗体磷脂酶C乙4(PLCb4)
目录 :
MBS2033947
规格 :
0.01毫克
价格 :
110美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
MyBioSource 产品网页
图像
图像 1 :
MyBioSource MBS2033947 图像 1
Western Blot: Sample: Recombinant protein.
产品信息
目录号 :
MBS2033947
产品类型 :
抗体
产品全称 :
多克隆抗体磷脂酶C乙4(PLCb4)
产品简称 :
[磷脂酶C乙4]
产品名称同义词 :
[PI-PLC; Phospholipase C-beta-4; Phosphoinositide phospholipase C-beta-4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4]
其他名称 :
[1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; phospholipase C beta 4; Phosphoinositide phospholipase C-beta-4; Phospholipase C-beta-4; PLC-beta-4]
产品基因名称 :
[PLCb4]
其他基因名称 :
[PLCB4;PLCB4;ARCND2;主要研究者-PLC;PLC乙]
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
人类
特异性 :
The antibody is a Rabbit polyclonal antibody raised against PLCb4. It has been selected for its ability to recognize PLCb4 in immunohistochemical staining and western blotting.
纯度 :
Antigen-specific Affinity Chromatography
形式 :
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol
浓度 :
200微克/毫升
储存稳定性 :
Storage: Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
检测过的应用 :
免疫印迹;免疫组化;免疫细胞化学;免疫沉淀
应用笔记 :
Western blotting: 0.5-2µg/mL. Immunocytochemistry in formalin fixed cells: 5-20µg/mL. Immunohistochemistry in formalin fixed frozen section: 5-20µg/mL. Immunohistochemistry in paraffin section: 5-20µg/mL. Optimal working dilutions must be determined by end user
image1头 :
免疫印迹(免疫印迹)
其它信息1 :
Source: Polyclonal antibody preparation. Traits: Liquid. Immunogen: Recombinant PLCb4 (Ala2~Gln250) expressed in E.coli
其他信息2 :
Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2073145
NCBI GI登录号 :
289547589
NCBI登录号 :
NP_000924.3
NCBI基因登录号 :
NM_000933.3
UniProt数据库登录号 :
Q15147
NCBI分子量 :
135,845 Da
NCBI信号通路 :
Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Calcium Signaling Pathway (83050)
NCBI总结 :
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
UniProt数据库总结 :
PLCB4: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. Defects in PLCB4 are the cause of auriculocondylar syndrome type 2 (ARCND2). ARCND2 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase. Chromosomal Location of Human Ortholog: 20p12.3-p12.2. Cellular Component: cytosol; dendrite; nucleus; postsynaptic density; smooth endoplasmic reticulum. Molecular Function: calcium ion binding; phosphoinositide phospholipase C activity; phospholipase C activity; protein binding; signal transducer activity. Biological Process: G-protein coupled receptor signaling pathway; inositol phosphate metabolic process; lipid catabolic process. Disease: Auriculocondylar Syndrome 2
尺寸1 :
0.01毫克
价格1 :
110美元
尺寸2 :
0.02毫克
价格2 :
130
size3 :
0.05毫克
价格3 :
175
size4 :
0.1毫克
price4 :
225
size5 :
0.2毫克
price5 :
340
size6 :
1毫克
price6 :
800
更多信息或购买 :
MyBioSource 产品网页
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。