产品简要
公司名称 :
MyBioSource
产品类型 :
蛋白
产品名称 :
NPM1, 1-294aa, 人类, 多聚组氨酸标签, 重组, 大肠杆菌
目录 :
MBS204570
规格 :
0.1毫克
价格 :
310美元
更多信息或购买 :
产品信息
目录号 :
MBS204570
产品类型 :
重组蛋白
产品全称 :
NPM1, 1-294aa, 人类, 多聚组氨酸标签, 重组, 大肠杆菌
产品简称 :
NPM1
产品名称同义词 :
Nucleophosmin; B23; NPM
其他名称 :
nucleophosmin isoform 1; Nucleophosmin; nucleophosmin; nucleolar protein NO38; nucleophosmin/nucleoplasmin family, member 1; nucleophosmin (nucleolar phosphoprotein B23, numatrin); Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin
产品基因名称 :
NPM1
其他基因名称 :
NPM1;NPM1;B23;NPM;NPM;NPM
UniProt数据库进入名 :
NPM_HUMAN
序列长度 :
294
序列 :
MGSSHHHHHH SSGLVPRGSH MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL RLKCGSGPVH ISGQHLVAVE EDAESEDEEE EDVKLLSISG KRSAPGGGSK VPQKKVKLAA DEDDDDDDEE DDDEDDDDDD FDDEEAEEKA PVKKSIRDTP AKNAQKSNQN GKDSKPSSTP RSKGQESFKK QEKTPKTPKG PSSVEDIKAK MQASIEKGGS LPKVEAKFIN YVKNCFRMTD QEAIQDLWQW RKSL
纯度 :
> 85% by SDS - PAGE
形式 :
液体。 20mM三羟甲基氨基甲烷氯化氢缓冲液(pH8.0)含10% 甘油0.15M氯化钠, 1mM DTT
浓度 :
0.5毫克/毫升(由布拉德福德Bradford检测确定)
储存稳定性 :
Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
检测过的应用 :
十二烷基磺酸钠-PAGE
其它信息1 :
Antigen Species: Human. Tag: His-tag
其他信息2 :
Expression System: E Coli
产品种类 :
Epigenomics
产品描述 :
NPM1 is a phosphoprotein which moves between the nucleus and the cytoplasm. It is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in NPM1 are associated with acute myeloid leukemia. Recombinant human NPM1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
产品引用 :
Sagawa,F., et al. (2011) EMBO J. 30 (19), 3994-4005. Neubauer,A., et al. (2011) Exp. Hematol. 39 (10), 1030-1042.
NCBI GI登录号 :
10835063
NCBI登录号 :
NP_002511
NCBI基因登录号 :
NM_002520.6
NCBI分子量 :
34.7kDa (314aa), confirmed by MALDI-TOF
NCBI信号通路 :
Aurora B Signaling Pathway (138080); BARD1 Signaling Events Pathway (137959); Cell Cycle Pathway (530733); Chromosome Maintenance Pathway (161048); Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway (161050); Disease Pathway (530764); HIF-1-alpha Transcription Factor Network Pathway (138045); HIV Infection Pathway (105983); Host Interactions Of HIV Factors Pathway (106010); Interactions Of Rev With Host Cellular Proteins Pathway (106014)
NCBI总结 :
This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
UniProt数据库总结 :
NPM1: a nucleolar protein associated with nucleolar ribonucleoprotein structures and that binds single-stranded nucleic acids. Is a major component of template activating factor (TAF)-III. It plays a role in controlling centrosome duplication, and may function in the assembly and/or transport of the ribosome. Two alternatively spliced isoforms have been described. Protein type: RNA-binding; Translation; Nucleolus; Oncoprotein. Chromosomal Location of Human Ortholog: 5q35.1. Cellular Component: nucleoplasm; centrosome; focal adhesion; membrane; cytoplasm; nucleolus; spindle pole centrosome; cytosol; ribonucleoprotein complex; nucleus. Molecular Function: NF-kappaB binding; protein binding; protein homodimerization activity; protein kinase inhibitor activity; histone binding; Tat protein binding; protein heterodimerization activity; RNA binding; unfolded protein binding; transcription coactivator activity; protein kinase binding; ribosomal large subunit binding; ribosomal small subunit binding. Biological Process: regulation of centriole replication; viral reproduction; positive regulation of translation; centrosome cycle; cell aging; nucleocytoplasmic transport; DNA repair; signal transduction; protein oligomerization; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; intracellular protein transport; nucleosome assembly; regulation of endodeoxyribonuclease activity; protein localization; DNA replication-independent nucleosome assembly at centromere; ribosome assembly; response to stress; negative regulation of apoptosis
尺寸1 :
0.1毫克
价格1 :
310美元
尺寸2 :
0.5毫克
价格2 :
720
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。