蛋白

FCGR3A, 18-208aa, 人类, 多聚组氨酸标签, 大肠杆菌

MBS204579

0.1毫克

310美元

重组蛋白

FCGR3A, 18-208aa, 人类, 多聚组氨酸标签, 大肠杆菌

FCGR3A

Low affinity immunoglobulin gamma Fc region receptor III-A; CD16; CD16A; FCG3; FCGR3; FCGRIII; FCR-10; FCRIII; FCRIIIA; IGFR3

low affinity immunoglobulin gamma Fc region receptor III-A isoform c; Low affinity immunoglobulin gamma Fc region receptor III-A; low affinity immunoglobulin gamma Fc region receptor III-A; CD16a antigen; Fc fragment of IgG, low affinity III, receptor for (CD16); Fc gamma receptor III-A; Fc-gamma RIII-alpha; Fc-gamma RIIIa; Fc-gamma receptor III-2 (CD 16); Fc-gamma receptor IIIb (CD16); FcgammaRIIIA; fc-gamma RIII; igG Fc receptor III-2; immunoglobulin G Fc receptor III; neutrophil-specific antigen NA; Fc fragment of IgG, low affinity IIIa, receptor (CD16a); CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2; CD_antigen: CD16a

FCGR3A

FCGR3A;FCGR3A;CD16;FCG3;CD16A;FCGR3;IGFR3;IMD20;FCR-10;FCRIII;FCGRIII;FCRIIIA;CD16A;FCG3;FCGR3;IGFR3;Fcγ受体Ⅲ;Fc丙RIIIa;FcRIII;FcRIIIa

FCG3A_HUMAN

254

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRT EDLPKAVVFL EPQWYRVLEK DSVTLKCQGA YSPEDNSTQW FHNESLISSQ ASSYFIDAAT VDDSGEYRCQ TNLSTLSDPV QLEVHIGWLL LQAPRWVFKE EDPIHLRCHS WKNTALHKVT YLQNGKGRKY FHHNSDFYIP KATLKDSGSY FCRGLFGSKN VSSETVNITI TQGLAVSTIS SFFPPGYQ

> 90% by SDS - PAGE

液体。 在20mM三羟甲基氨基甲烷氯化氢缓冲液(pH值8.0)含1M尿素, 10% 甘油

1毫克/毫升(由布拉德福德Bradford检测确定)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

十二烷基磺酸钠-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

免疫学

Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A), also known as CD16A. This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other antibody-dependent responses. FCGR3A requires association of the gamma subunit of Fc epsilon RI or the zeta subunit of the TCR-CD3 complex for cell surface expression. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Recombinant human FCGR3A protein, fused to His-tag at N-terminus, was expressed in E.coli.

Huizinga T W., et al. (1988) Nature. 333:667-669. Nagarajan S., et al. (1995) J Biol Chem. 270:25762-25770.

189083838

NP_001121065

NM_001127593.1

26 kDa (228aa)

Adaptive Immune System Pathway (366160); FCGR Activation Pathway (771578); Fc Gamma R-mediated Phagocytosis Pathway (114228); Fc Gamma R-mediated Phagocytosis Pathway (106590); Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway (771577); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413); Innate Immune System Pathway (106387); Leishmaniasis Pathway (144181); Leishmaniasis Pathway (144028)

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

FCGR3A: Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q23. Cellular Component: integral to membrane; plasma membrane; external side of plasma membrane. Molecular Function: IgG binding. Biological Process: regulation of immune response; innate immune response; immune response. Disease: Immunodeficiency 20

0.1毫克

310美元

0.5毫克

720