蛋白

DSTN, 1-165aa, 人类, 多聚组氨酸标签, 大肠杆菌

MBS204618

0.1毫克

310美元

重组蛋白

DSTN, 1-165aa, 人类, 多聚组氨酸标签, 大肠杆菌

DSTN

Destrin (actin depolymerizing factor); ACTDP; ADF; bA462D18.2

destrin isoform a; Destrin; destrin; actin-depolymerizing factor; bA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP)); epididymis luminal protein 32; destrin (actin depolymerizing factor); Actin-depolymerizing factor; ADF

DSTN

DSTN;DSTN;ADF;ACTDP;HEL32;bA462D18.2;ACTDP;DSN;ADF

DEST_HUMAN

165

MASGVQVADE VCRIFYDMKV RKCSTPEEIK KRKKAVIFCL SADKKCIIVE EGKEILVGDV GVTITDPFKH FVGMLPEKDC RYALYDASFE TKESRKEELM FFLWAPELAP LKSKMIYASS KDAIKKKFQG IKHECQANGP EDLNRACIAE KLGGSLIVAF EGCPVLEHHH HHH

> 95% by SDS - PAGE

液体。 在20mM三羟甲基氨基甲烷氯化氢缓冲液(pH值8.0)含0.1M氯化钠, 10% 甘油, 1mM DTT

0.5毫克/毫升(由布拉德福德Bradford检测确定)

Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.

十二烷基磺酸钠-PAGE

Antigen Species: Human. Tag: His-tag

Expression System: E Coli

Actin & Myosin Related

Destrin (actin depolymerizing factor), also known as DSTN, is a member of the ADF/Cofilin/destrin superfamily that has the ability to rapidly depolymerize F-Actin in a stoichiometric manner. DSTN is a small phosphoinositide-sensitive actin-binding protein capable of depolymerizing actin-filaments in vitro. It is found in various epithelial and endothelial cells but is practically absent from adult mouse heart and skeletal muscle cells. DSTN shares 71% sequence homology with Cofilin, however the two proteins differ in their interaction with Actin. Recombinant human DSTN protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Nishida E., et al. (1985) Biochemistry. 24:6624-6630. Kanamori T., et al. (1995) J Biol Chem. 270: 8061-8067.

5802966

NP_006861

NM_006870.3

19.5 kDa (173aa) confirmed by MALDI-TOF

Androgen Receptor Signaling Pathway (198806)

The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Destrin: an actin-depolymerizing cytoskeletal protein that belongs to the ADF actin-binding protein family. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Present in many vertebrate tissues and particularly abundant in neuronal cells. It binds F-actin in a pH-dependent manner which affects it s severing/depolymerizing activities. It also binds G-actin at pH 8.0 thereby sequestering monomers and preventing polymerization. Protein type: Motility/polarity/chemotaxis; Actin-binding. Chromosomal Location of Human Ortholog: 20p12.1. Cellular Component: cortical actin cytoskeleton; actin cytoskeleton. Molecular Function: actin binding. Biological Process: actin filament severing; actin filament depolymerization; positive regulation of actin filament depolymerization; actin polymerization and/or depolymerization

0.1毫克

310美元

0.5毫克

720