抗体

MOUSE抗人类CD284:Biotin

MBS210389

0.1毫克

415美元

单克隆

小鼠

生物素

HTA125

流式细胞仪, 流式细胞仪

抗体

MOUSE抗人类CD284:Biotin

CD284

toll-like receptor 4 isoform C; Toll-like receptor 4; toll-like receptor 4; hToll; homolog of Drosophila toll; toll-like receptor 4; hToll; CD_antigen: CD284

CD284

Toll样受体4;Toll样受体4;TOLL;CD284;TLR-4;ARMD10

TLR4_HUMAN

单克隆

IgG2a

HTA125

小鼠

639

Biotin. Purified IgG conjugated to Biotin - liquid

IgG浓度0.1毫克/毫升

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

流式细胞仪(FC/流式细胞仪)

Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells or cells or 100ul whole blood.

Perservative Stabilisers: 0.09% Sodium Azide. 1% Bovine Serum Albumin. Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Immunogen: Ba/F3 cell line expressing TLR4 (CD284). Fusion Partners: Spleen cells from immunised Balb/c mice were fused with cells of the mouse SP2/0 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Human

Mouse anti Human CD284 antibody, clone HTA125 recognizes the human Toll like receptor 4 (TLR4) cell surface antigen. TLR4, also known as CD284, has been demonstrated to act as a receptor for LPS on human monocytes and macrophages. TLR4 signalling of LPS stimulation requires the presence of the MD-2 molecule. TLR4 is weakly expressed by resting cells, but is upregulated following stimulation with LPS. This antibody has been demonstrated to block activation of monocytes with LPS. MyBioSource recommend the use of MBS211211 for this purpose.

4507533

NP_003257.1

NM_003266.3

O00206

73,301 Da

Activated TLR4 Signalling Pathway 106400!!Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway 187088!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Corticotropin-releasing Hormone Pathway 920957!!HIF-1 Signaling Pathway 695200!!Hepatitis B Pathway 694606!!IKK Complex Recruitment Mediated By RIP1 Pathway 187090

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

0.1毫克

415美元