抗体

MOUSE抗人类细胞角蛋白19

MBS211749

0.2毫克

390美元

单克隆

小鼠

未共轭

A53-B/A2

免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 酶免疫法

抗体

MOUSE抗人类细胞角蛋白19

细胞角蛋白19

keratin, type I cytoskeletal 19; Keratin, type I cytoskeletal 19; keratin, type I cytoskeletal 19; 40-kDa keratin intermediate filament; CK-19; cytokeratin 19; cytokeratin-19; keratin, type I, 40-kd; keratin 19, type I; Cytokeratin-19; CK-19; Keratin-19; K19

KRT19;KRT19;K19;CK19;K1CS;CK-19;K19

K1C19_HUMAN

单克隆

IgG2a

A53-B/A2

小鼠

400

纯化。 纯化IgG-液体

Approximate Protein Concentration: 1.0 mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Shelf Life: 18 months from date of despatch.

ELISA (EIA), Immunofluorescence (IF), Immunohistology Paraffin*, Western Blot (WB)

Western Blot: In Western blotting 40 kD and 19 kD bands are observed. Immunohistology - Paraffin: Minimum Dilution: 1/100; Maximum Dilution: 1/200; Application Note: This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase.

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Histology Positive Control Tissue: Appendix. Buffer Solution: Phosphate buffered saline. Target Species: Human

Mouse anti Human cytokeratin 19 antibody, clone A53-B/A2 recognizes the rod domain (aa 312-335) of human cytokeratin 19 (B ttger; et al. 1995) also known as keratin 19 encoded by the KRT19 gene. Cytokeratin 19 is a 400 amino acid intermediate filament protein lacking a C-terminal tail domain, in contrast to all other intermediate filament proteins. Cytokeratin 19 expression is observed in striated muscle where it is involved in forming the association between the contractile apparatus and dystrophin (Stone et al. 2005). Expression is also seen in many ductal and glandular cells together with a restricted set of normal and neoplasic epithelial cells. Mouse anti Human cytokeratin 19 antibody, clone A53-B/A2 detects a band of ~45 kDA in Western blotting using an A-549 human alveolar adenocarcinoma cell line lysate.

24234699

NP_002267.2

NM_002276.4

P08727

44,106 Da

Signaling Mediated By P38-alpha And P38-beta Pathway (138012)

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

K19: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 19 differs from all other IF proteins in lacking the C-terminal tail domain. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 17q21.2. Cellular Component: dystrophin-associated glycoprotein complex; costamere; intermediate filament; Z disc; sarcolemma. Molecular Function: protein binding; structural constituent of cytoskeleton; structural constituent of muscle; protein complex binding. Biological Process: viral reproduction; response to estrogen stimulus; sarcomere organization

0.2毫克

390美元