产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
MOUSE抗人类SNAP-25
目录 :
MBS212090
规格 :
0.2毫克
价格 :
405美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
SP12
反应物种 :
人类, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS212090
产品类型 :
抗体
产品全称 :
MOUSE抗人类SNAP-25
产品简称 :
SNAP-25
其他名称 :
synaptosomal-associated protein 25 isoform SNAP25A; Synaptosomal-associated protein 25; synaptosomal-associated protein 25; SUP; resistance to inhibitors of cholinesterase 4 homolog; super protein; synaptosomal-associated protein, 25kD; synaptosomal-associated protein, 25kDa; Super protein; SUP; Synaptosomal-associated 25 kDa protein
产品基因名称 :
SNAP-25
其他基因名称 :
SNAP25;SNAP25;RIC4;SEC9;SNAP;RIC-4;SNAP-25;bA416N4.2;dJ1068F16.2;SNAP;SNAP-25;SUP
UniProt数据库进入名 :
SNP25_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG1
克隆 :
SP12
宿主 :
小鼠
反应物种 :
Gerbil, Hamster, Pig, Rat
序列长度 :
206
形式 :
纯化。 纯化IgG-液体
浓度 :
IgG浓度1.0毫克/毫升
储存稳定性 :
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
检测过的应用 :
ELISA (EIA), Immunohistology Paraffin, Western Blot (WB)
应用笔记 :
Immunohistology: This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Immunohistology - Paraffin: Minimum Dilution: 1/2000; Maximum Dilution: 1/5000. Western Blotting: Minimum Dilution: 1/500; Maximum Dilution: 1/5000
其它信息1 :
Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
其他信息2 :
Histology Positive Control Tissue: Brain. Buffer Solution: Phosphate buffered saline. Target Species: Human
产品描述 :
Mouse anti Human SNAP-25 antibody, clone SP12 recognizes the human pre-synaptic protein, SNAP-25, also known as Synaptosomal-associated protein 25, Super protein (SUP) or Synaptosomal-associated 25 kDa protein. SNAP-25 is a 206 amino acid  presynaptic protein of ~25kDa containing two t-SNARE coiled-coil homology domains. Mouse anti human SNAP-25 antibody, clone SP12 will recognize SNAP-25 fusion protein from COS cells, but not the fusion protein from bacterial systems. Mouse anti Human SNAP-25 antibody, clone SP12  has been used to study the distribution of synaptic changes in the hippocampus of patients with medically refractory temporal lobe epilepsy. (Honer et al. 1994).
NCBI GI登录号 :
18765733
NCBI登录号 :
NP_003072.2
NCBI基因登录号 :
NM_003081.3
UniProt数据库登录号 :
P60880
NCBI分子量 :
23,336 Da
NCBI信号通路 :
Acetylcholine Neurotransmitter Release Cycle Pathway (106525); Disease Pathway (530764); Dopamine Neurotransmitter Release Cycle Pathway (106523); Effects Of Botulinum Toxin Pathway (138028); GABA Synthesis, Release, Reuptake And Degradation Pathway (187174); Glutamate Neurotransmitter Release Cycle Pathway (106522); Insulin Signaling Pathway (198845); Insulin Secretion Pathway (777534); Integration Of Energy Metabolism Pathway (106096); Metabolism Pathway (477135)
NCBI总结 :
Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
SNAP-25: a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Part of the SNARE core complex containing SNAP25, VAMP2 and syntaxin 1A. Associates with proteins involved in vesicle docking and membrane fusion. Two alternatively spliced isoforms have been described. Protein type: Vesicle. Chromosomal Location of Human Ortholog: 20p12-p11.2. Cellular Component: presynaptic membrane; SNARE complex; neuron projection; growth cone; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; trans-Golgi network; cell junction; cytosol; vesicle. Molecular Function: SNAP receptor activity; protein binding; syntaxin-1 binding; calcium-dependent protein binding. Biological Process: synaptic vesicle fusion to presynaptic membrane; synaptic transmission; synaptic vesicle exocytosis; glutamate secretion; neurotransmitter secretion; energy reserve metabolic process; neurotransmitter uptake; pathogenesis; regulation of insulin secretion; synaptic vesicle priming; synaptic vesicle docking during exocytosis. Disease: Myasthenic Syndrome, Congenital, 18
尺寸1 :
0.2毫克
价格1 :
405美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。