抗体

MOUSE抗人类CD95

MBS212192

0.2毫克

415美元

单克隆

小鼠

未共轭

LOB 3/17

人类, 猕猴

免疫沉淀, 流式细胞仪, 流式细胞仪

抗体

MOUSE抗人类CD95

CD95

tumor necrosis factor receptor superfamily member 6 isoform 1; Tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily member 6; APO-1 cell surface antigen; CD95 antigen; Delta Fas/APO-1/CD95; FAS 827dupA; FAS receptor variant 9; FASLG receptor; Fas (TNF receptor superfamily, member 6); Fas AMA; TNF receptor superfamily member 6; apoptosis antigen 1; apoptosis-mediating surface antigen FAS; tumor necrosis factor receptor superfamily, member 6; Fas cell surface death receptor; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; CD_antigen: CD95

CD95

肿瘤坏死因子受体超家族成员6;肿瘤坏死因子受体超家族成员6;APT1;CD95;FAS1;ApoE基因-1;FASTM;ALPS1A;TNFRSF6;APT1;FAS1;TNFRSF6

TNR6_HUMAN

单克隆

IgG1

LOB 3/17

小鼠

猕猴

220

纯化。 纯化IgG-液体

IgG浓度1.0毫克/毫升

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

流式细胞仪(FC/流式细胞仪), 免疫沉淀(免疫沉淀)

Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100. Immunoprecipitation: Maximum Dilution: 20ug/ml

Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein A

Immunogen: Fusion protein comprising extracellular domain of human Fas linked to human Fc. Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the mouse NSI myeloma cell line. Buffer Solution: TRIS buffered saline. Target Species: Human

Mouse anti Human CD95 antibody, clone LOB 3/17 recognizes the human CD95 cell surface antigen, a 40-50kDa glycoprotein expressed by activated T and B cells, NK cells and thymocytes.

4507583

NP_000034.1

NM_000043.4

P25445

24,781 Da

Adipogenesis Pathway (198832); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Allograft Rejection Pathway (920963); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Apoptosis Pathway (198797)

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]

FAS: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD. Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Apoptosis; Cell surface; Receptor, cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 10q24.1. Cellular Component: cell surface; cytoplasm; integral to membrane; plasma membrane; CD95 death-inducing signaling complex; nucleus; cytosol; lipid raft; external side of plasma membrane. Molecular Function: identical protein binding; signal transducer activity; protein binding; transmembrane receptor activity; receptor activity; kinase binding. Biological Process: circadian rhythm; caspase activation; spleen development; regulation of myeloid cell differentiation; renal system process; transformed cell apoptosis; positive regulation of apoptosis; apoptosis; positive regulation of protein homooligomerization; regulation of lymphocyte differentiation; response to toxin; response to glucocorticoid stimulus; negative regulation of B cell activation; signal transduction; negative thymic T cell selection; regulation of apoptosis; inflammatory cell apoptosis; B cell mediated immunity; induction of apoptosis via death domain receptors; protein complex assembly; gene expression; immunoglobulin production; activated T cell apoptosis; protein homooligomerization; negative regulation of apoptosis. Disease: Autoimmune Lymphoproliferative Syndrome

0.2毫克

415美元