抗体

MOUSE抗人类CD14

MBS212217

0.2毫克

415美元

单克隆

小鼠

未共轭

TUK4

人类, 狗, 牛

免疫印迹, 酶联免疫吸附测定, 流式细胞仪, 流式细胞仪, 酶免疫法

抗体

MOUSE抗人类CD14

CD14

monocyte differentiation antigen CD14; Monocyte differentiation antigen CD14; monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein; CD14 molecule; Myeloid cell-specific leucine-rich glycoprotein; CD_antigen: CD14Cleaved into the following 2 chains:Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form

CD14

CD14;CD14

CD14_HUMAN

单克隆

IgG2a

TÜK4

小鼠

Bovine, Cat, Cynomolgus monkey, Dog, Goat, Llama, Mink, Pig, Rabbit, Sheep

375

纯化。 纯化IgG-液体

IgG浓度1.0毫克/毫升

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

酶联免疫吸附测定(EIA), 流式细胞仪(FC/流式细胞仪), 免疫印迹(免疫印迹)

Flow Cytometry: Use 5ul of the suggested working dilution to label 106 cells or 100ul whole blood. Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/200

Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant.

Buffer Solution: Phosphate buffered saline. Target Species: Human

4557417

NP_000582.1

NM_000591.3

40,076 Da

Activated TLR4 Signalling Pathway (106400); Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway (187088); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); IKK Complex Recruitment Mediated By RIP1 Pathway (187090); Immune System Pathway (106386); Innate Immune System Pathway (106387); Legionellosis Pathway (469200)

The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]

CD14: Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules. Protein type: Membrane protein, GPI anchor. Chromosomal Location of Human Ortholog: 5q31.1. Cellular Component: extracellular space; cell surface; plasma membrane; extracellular region; endosome membrane; lipid raft. Molecular Function: peptidoglycan receptor activity; protein binding; opsonin receptor activity; lipopolysaccharide binding. Biological Process: I-kappaB kinase/NF-kappaB cascade; apoptosis; MyD88-independent toll-like receptor signaling pathway; positive regulation of endocytosis; toll-like receptor 3 signaling pathway; positive regulation of tumor necrosis factor production; phagocytosis; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; response to magnesium ion; response to ethanol; cell surface receptor linked signal transduction; response to heat; toll-like receptor signaling pathway; innate immune response; inflammatory response; response to electrical stimulus; toll-like receptor 4 signaling pathway; positive regulation of cytokine secretion

0.2毫克

415美元