产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
MOUSE抗大鼠CD172a
目录 :
MBS212963
规格 :
0.1毫克
价格 :
190美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
OX-41
反应物种 :
大鼠
应用 :
流式细胞仪, 流式细胞仪
更多信息或购买 :
产品信息
目录号 :
MBS212963
产品类型 :
抗体
产品全称 :
MOUSE抗大鼠CD172a
产品简称 :
CD172a
其他名称 :
tyrosine-protein phosphatase non-receptor type substrate 1; Tyrosine-protein phosphatase non-receptor type substrate 1; tyrosine-protein phosphatase non-receptor type substrate 1; Brain immunoglobulin like protein with tyrosine - based activation motifs; CD172 antigen-like family member A; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1); brain Ig-like molecule with tyrosine-based activation motifs; inhibitory receptor SHPS-1; macrophage fusion receptor; macrophage membrane protein MFP150; signal-regulatory protein alpha-1; sirp-alpha-1; signal-regulatory protein alpha; Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; Macrophage membrane protein MFP150; Signal-regulatory protein alpha-1; Sirp-alpha-1; CD_antigen: CD172a
产品基因名称 :
CD172a
其他基因名称 :
Sirpa; Sirpa; Bit; Ptpns1; SHPS-1; Bit; Mfr; Ptpns1; Shps1; Sirp; SHP substrate 1; SHPS-1; Bit; Sirp-alpha-1
UniProt数据库进入名 :
SHPS1_RAT
克隆性 :
单克隆
抗体亚型 :
IgG2a
克隆 :
OX-41
宿主 :
小鼠
序列长度 :
509
形式 :
纯化。 纯化IgG-液体
浓度 :
IgG浓度1.0毫克/毫升
储存稳定性 :
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
检测过的应用 :
Immunohistology Frozen, Flow cytometry (FC/FACS), Immunohistology Paraffin*
应用笔记 :
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Flow Cytometry: Minimum Dilution: 1/100; Maximum Dilution: 1/200. Immunohistology - Paraffin: Application Note: This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase.
其它信息1 :
Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
其他信息2 :
Buffer Solution: Phosphate buffered saline. Target Species: Rat
产品描述 :
Mouse anti Rat CD172a antibody, clone OX-41 recognizes rat CD172a, also known as Signal regulatory protein (SIRP). CD172a is expressed selectively by myeloid cells and by neurons. MRC OX-41 binds to a different epitope on SIRP than ED9. It does not block the interaction of CD172a - CD47.
NCBI GI登录号 :
31543529
NCBI登录号 :
NP_037148.2
NCBI基因登录号 :
NM_013016.2
UniProt数据库登录号 :
P97710
NCBI分子量 :
55,691 Da
NCBI信号通路 :
Cell Surface Interactions At The Vascular Wall Pathway (1120553); Cell-Cell Communication Pathway (1121445); DAP12 Interactions Pathway (1121612); Hemostasis Pathway (1120520); IL-1 Signaling Pathway (198458); Immune System Pathway (1121507); Innate Immune System Pathway (1121536); Osteoclast Differentiation Pathway (193140); Osteoclast Differentiation Pathway (193096); Signal Regulatory Protein (SIRP) Family Interactions Pathway (1121455)
NCBI总结 :
plays a role in macrophage fusion [RGD, Feb 2006]
UniProt数据库总结 :
SHPS1: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR. Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B. Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Cell adhesion; Cell surface; Motility/polarity/chemotaxis; Receptor, misc. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: protein phosphorylated amino acid binding; protein binding; SH3 domain binding. Biological Process: cell migration; positive regulation of phagocytosis; cell-matrix adhesion; actin filament organization; cytoskeleton organization and biogenesis; hemopoietic progenitor cell differentiation; phagocytosis, recognition; phagocytosis, engulfment
尺寸1 :
0.1毫克
价格1 :
190美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。