产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
MOUSE抗人类CD120a:FITC
目录 :
MBS214946
规格 :
0.025毫克
价格 :
175美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
异硫氰酸荧光素
克隆名称 :
H398
反应物种 :
人类
应用 :
流式细胞仪, 流式细胞仪
更多信息或购买 :
产品信息
目录号 :
MBS214946
产品类型 :
抗体
产品全称 :
MOUSE抗人类CD120a:FITC
产品简称 :
CD120a
其他名称 :
tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor superfamily member 1A; tumor necrosis factor receptor superfamily member 1A; TNF-R1; TNF-RI; TNFR-I; tumor necrosis factor binding protein 1; tumor necrosis factor receptor 1A isoform beta; tumor necrosis factor receptor type 1; tumor necrosis factor-alpha receptor; tumor necrosis factor receptor superfamily, member 1A; Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60; CD_antigen: CD120aCleaved into the following 2 chains:Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1; TBPI
产品基因名称 :
CD120a
其他基因名称 :
肿瘤坏死因子受体超家族成员1A;肿瘤坏死因子受体超家族成员1A;FPF;MS5;p55;p60;TBP1;肿瘤坏死因子-R;TNFAR;TNFR1;p55-R;CD120a;TNFR55;TNFR60;肿瘤坏死因子-R;肿瘤坏死因子-R55;TNFR1-d2;TNFAR;TNFR1;肿瘤坏死因子-R1;肿瘤坏死因子-RI;TNFR-I;TBPI
UniProt数据库进入名 :
TNR1A_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG2a
克隆 :
H398
宿主 :
小鼠
序列长度 :
455
形式 :
FITC. Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
浓度 :
IgG浓度0.1毫克/毫升
储存稳定性 :
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
检测过的应用 :
流式细胞仪(FC/流式细胞仪)
应用笔记 :
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood. Flow Cytometry: Maximum Dilution: Neat
其它信息1 :
Perservative Stabilisers: 0.09% Sodium Azide. 1% Bovine Serum Albumin. Preparation: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
其他信息2 :
Buffer Solution: Phosphate buffered saline. Target Species: Human
产品描述 :
Mouse anti Human CD120a antibody, clone H398 recognizes an extracellular domain of the 55kDa human TNF receptor (p55, TNF-R1, CD120a). No binding occurs to the 75kDa TNF receptor (CD120b). CD120a is weakly expressed by monocytes and granulocytes. Mouse anti Human CD120a antibody, clone H398 may be used to detect high levels of TNFR1, in western blotting under reducing conditions, such as recombinant material, but it is not suitable for detection of TNFR1 in normal cells in this application. Mouse anti Human CD120a antibody, clone H398 inhibits the biological activity of both natural and recombinant human TNFalpha and TNFbeta (Thoma et al. 1990and Dri et al. 1999). Mouse anti Human CD120a antibody, clone H398 is routinely tested in flow cytometry on human peripheral blood monocytes.
NCBI GI登录号 :
4507575
NCBI登录号 :
NP_001056.1
NCBI基因登录号 :
NM_001065.3
UniProt数据库登录号 :
P19438
NCBI分子量 :
24,194 Da
NCBI信号通路 :
Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Apoptosis Pathway (198797); Apoptosis Pathway (83060)
NCBI总结 :
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
TNF-R1: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. Interacts with human cytomegalovirus/HHV-5 protein UL138. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 12p13.2. Cellular Component: Golgi membrane; extracellular space; cell surface; mitochondrion; axon; integral to plasma membrane; plasma membrane; extracellular region; synapse; nucleus; cytosol; receptor complex; lipid raft. Molecular Function: protein binding; tumor necrosis factor receptor activity; protease binding; protein complex binding; tumor necrosis factor binding. Biological Process: response to alkaloid; viral reproduction; protein heterooligomerization; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway; positive regulation of neuron apoptosis; response to wounding; negative regulation of interleukin-6 production; tetrapyrrole metabolic process; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein import into nucleus, translocation; cytokine and chemokine mediated signaling pathway; response to amino acid stimulus; positive regulation of tumor necrosis factor production; prostaglandin metabolic process; positive regulation of angiogenesis; positive regulation of tyrosine phosphorylation of Stat1 protein; response to ethanol; DNA damage response, signal transduction resulting in induction of apoptosis; induction of apoptosis via death domain receptors; negative regulation of inflammatory response; defense response to bacterium; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; positive regulation of inflammatory response; negative regulation of apoptosis. Disease: Periodic Fever, Familial, Autosomal Dominant; Multiple Sclerosis, Susceptibility To, 5
尺寸1 :
0.025毫克
价格1 :
175美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。