产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
大鼠抗MOUSE CD115
目录 :
MBS215326
规格 :
0.1毫克
价格 :
335美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
[604B5 2E11]
反应物种 :
小鼠
应用 :
流式细胞仪, 流式细胞仪
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS215326 图像 1
Staining of the mouse J774 cell line with Rat anti Mouse CD115 : RPE (MBS215327)
产品信息
目录号 :
MBS215326
产品类型 :
抗体
产品全称 :
大鼠抗MOUSE CD115
产品简称 :
[CD115]
其他名称 :
[macrophage colony-stimulating factor 1 receptor; Macrophage colony-stimulating factor 1 receptor; macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; c-fms; proto-oncogene c-Fms; proto-oncogene fms; colony stimulating factor 1 receptor; CSF-1 receptor (EC:2.7.10.1); CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD_antigen: CD115]
产品基因名称 :
[CD115]
其他基因名称 :
[Csf1r; Csf1r; Fms; CD115; Csfmr; Fim-2; CSF-1R; M-CSFR; M-CSF-R; AI323359; Csfmr; Fms; CSF-1-R; CSF-1R; M-CSF-R]
UniProt数据库进入名 :
CSF1R_MOUSE
克隆性 :
单克隆
抗体亚型 :
IgG1
克隆 :
[604B5 2E11]
宿主 :
大鼠
序列长度 :
977
形式 :
纯化。 纯化IgG-液体
浓度 :
IgG浓度1.0毫克/毫升
储存稳定性 :
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
检测过的应用 :
流式细胞仪(FC/流式细胞仪)
应用笔记 :
Flow Cytometry: Use 10ul of the suggested working dilution to label 10 6 cells in 100ul. Flow Cytometry: Minimum Dilution: 1/25; Maximum Dilution: 1/50
image1头 :
试验数据
其它信息1 :
Perservative Stabilisers: 0.09% Sodium Azide. Preparation: Purified IgG prepared by ion exchange chromatography
其他信息2 :
Immunogen: Raw 264 cells. Fusion Partners: Spleen cells from immunised Sprague Dawley rats were fused with cells of the P3-653 myeloma cell line. Buffer Solution: Phosphate buffered saline. Target Species: Mouse
产品描述 :
Rat anti Mouse CD115 antibody, clone 604B5 2E11 recognizes the murine CD115 cell surface antigen, also known as the M-CSF receptor and as c-fms. CD115 is expressed by cells of the monocytic lineage and by progenitor cells. Rat anti Mouse CD115 antibody, clone 604B5 2E11 has been shown to inhibit in vitro colony formation in response to M-CSF in both rats and mice.
NCBI GI登录号 :
126723423
NCBI登录号 :
NP_001032948.2
NCBI基因登录号 :
NM_001037859.2
UniProt数据库登录号 :
P09581
NCBI分子量 :
109,179 Da
NCBI信号通路 :
Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); Endocytosis Pathway (102286); Endocytosis Pathway (102181); Hematopoietic Cell Lineage Pathway (83275); Hematopoietic Cell Lineage Pathway (489); Osteoclast Differentiation Pathway (193149); Osteoclast Differentiation Pathway (193096); PI3K-Akt Signaling Pathway (692242); PI3K-Akt Signaling Pathway (692979)
UniProt数据库总结 :
CSFR: an oncogenic tyrosine kinase receptor for CSF-1 (M-CSF). Drives growth and development of monocytes. Binding of CSF-1 induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins. There are at least five major tyrosine autophosphorylation sites. Two point mutations seen in 10-20% of patients with acute myeloid leukemia, chronic myelomonocytic leukemia or myelodysplasia. One mutation appears to be both somatic and germline, and disrupts Cbl binding and receptor turnover. v-fms lacks the Cbl binding site and causes feline leukemia. Mutations may also develop after chemotherapy for lymphoma. A distinct point mutation was found in some cases of hepatocellular carcinoma and related to increased expression, and another mutation was found in 2 of 40 patients with idiopathic myelofibrosis. Expression is elevated in breast tumors and cell lines, and expression in xenografts and transgenic mice has been correlated with xenograft growth and breast cancer development. Inhibitors: Ki-20227 and other Kit/PDGFR inhibitors. Protein type: EC 2.7.10.1; Kinase, protein; Oncoprotein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; PDGFR family. Cellular Component: cell surface; membrane; plasma membrane; integral to membrane; intracellular; receptor complex. Molecular Function: transferase activity; macrophage colony stimulating factor receptor activity; protein binding; protein homodimerization activity; protein-tyrosine kinase activity; cytokine binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; protein phosphatase binding; ATP binding; protein kinase activity. Biological Process: regulation of bone resorption; phosphoinositide-mediated signaling; peptidyl-tyrosine phosphorylation; immune system process; positive regulation of osteoclast differentiation; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; osteoclast differentiation; protein amino acid phosphorylation; positive regulation of tyrosine phosphorylation of Stat3 protein; cell proliferation; regulation of cell shape; positive regulation of cell proliferation; ruffle organization and biogenesis; innate immune response; hemopoiesis; phosphatidylinositol metabolic process; positive regulation of protein amino acid phosphorylation; intercellular junction maintenance; inflammatory response; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
尺寸1 :
0.1毫克
价格1 :
335美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。