抗体

兔抗AKT1(N-末端)

MBS221849

0.1毫克

320美元

多克隆

兔

nonconjugated

人类, 小鼠, 大鼠

抗体

兔抗AKT1(N-末端)

AKT1

RAC-alpha serine/threonine-protein kinase; RAC-alpha serine/threonine-protein kinase; RAC-alpha serine/threonine-protein kinase; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-oncogene c-Akt; rac protein kinase alpha; v-akt murine thymoma viral oncogene homolog 1; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha

AKT1

AKT1;AKT1;AKT;PKB;RAC;CWS6;PRKBA;PKB-甲;RAC-甲;PKB;RAC;PKB;PKB甲

AKT1_HUMAN

多克隆

IgG

兔

小鼠, 大鼠

480

This item recognises the N-terminal region of Akt1, a 48kDa protein kinase forming part of the PI3K-Akt signalling pathway, known to regulate cell growth, proliferation and survival. The PI3K-Akt1 pathway is negatively regulated by the tumour suppressor PTEN. Excessive Akt1 activation can lead to the formation of malignant tumours, and has been associated with prostate cancer progression.

Purified. Purified IgG - liquid

IgG浓度1.0毫克/毫升

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

免疫印迹(免疫印迹)

Western Blot: This item detects a band of approximately 48 kDa in human liver cell lysates. Western Blotting: Maximum Dilution: 1.0ug/ml

Perservative Stabilisers: 0.02% Sodium Azide

Immunogen: A 16 amino acid peptide located near the human Akt1 amino-terminus. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to human Akt1 (NT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. Target Species: Human

MBS221849 recognises the N-terminal region of Akt1, a 48kDa protein kinase forming part of the PI3K-Akt signalling pathway, known to regulate cell growth, proliferation and survival. The PI3K-Akt1 pathway is negatively regulated by the tumour suppressor PTEN. Excessive Akt1 activation can lead to the formation of malignant tumours, and has been associated with prostate cancer progression.

62241013

NP_001014431.1

NM_001014431.1

P31749

48,347 Da

AGE/RAGE Pathway 698754!!AKT Phosphorylates Targets In The Cytosol Pathway 106475!!AKT Phosphorylates Targets In The Nucleus Pathway 106476!!AKT-mediated Inactivation Of FOXO1A Pathway 106333!!AMPK Signaling Pathway 198868!!AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Activation Of BAD And Translocation To Mitochondria Pathway 105659!!Activation Of BH3-only Proteins Pathway 105658!!Acute Myeloid Leukemia Pathway 83117

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]

0.1毫克

320美元