产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
兔抗人类CTGF
目录 :
MBS222751
规格 :
0.1毫克
价格 :
540美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS222751
产品类型 :
抗体
产品全称 :
兔抗人类CTGF
产品简称 :
CTGF
其他名称 :
connective tissue growth factor; Connective tissue growth factor; connective tissue growth factor; CCN family member 2; IBP-8; IGF-binding protein 8; IGFBP-8; hypertrophic chondrocyte-specific protein 24; insulin-like growth factor-binding protein 8; connective tissue growth factor; CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP-8
产品基因名称 :
CTGF
其他基因名称 :
CTGF;CTGF;CCN2;NOV2;HCS24;IGFBP8;CCN2;HCS24;IGFBP8;IBP-8;IGF结合蛋白8;IGFBP-8
UniProt数据库进入名 :
CTGF_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
序列长度 :
349
形式 :
Purified. Purified IgG - lyophilised
浓度 :
IgG concentration 1.0mg/ml after reconstitution.
储存稳定性 :
Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of reconstitution.
检测过的应用 :
ELISA (EIA), Functional Assays (FN), Immunofluorescence (IF), Immunohistology Paraffin*, Western Blot (WB)
应用笔记 :
ELISA: This purified human CTGF antibody may ne used in an indirect ELISA or as the capture reagent in a sandwich ELISA with our biotinylated human CTGF antibody as the detection reagent and recombinant human CTGF as the standard. ELISA: Minimum Dilution: 0.5; Maximum Dilution: 2.0ug/ml. Functional Assays: Minimum Dilution: 6.0; Maximum Dilution: 9.0ug/ml. Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. . Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml
其它信息1 :
Reconstitution: Reconstitute with 0.1ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended. NB: For functional studies do not add azide.
其他信息2 :
Immunogen: Recombinant human CTGF. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to human CTGF were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. Target Species: Human
产品描述 :
Rabbit anti Human CTGF antibody specifically recognizes human CTGF (connective tissue growth factor), a 323 amino acid polypeptide and member of the CCN family of secreted cysteine rich regulatory proteins, which is produced by vascular endothelial and umbilical vein cells, and interacts with several other growth factors, including transforming growth factor beta (TGF-beta), vascular endothelial growth factor (VEGF) and bone morphogenetic proteins (BMPs). CTGF is a heparin-binding pleiotropic growth factor involved in chondrogenesis and potentially skeletogenesis. CTGF promotes the adhesion of epithelial cells and fibroblasts, stimulates integrin expression, and also promotes endothelial cell survival, migration and adhesion, implicating CTGF in angiogenesis. CTGF induces extracellular matrix formation, including the deposition of excessive collagen in fibrotic diseases, and has also been implicated in wound healing.
NCBI GI登录号 :
4503123
NCBI登录号 :
NP_001892.1
NCBI基因登录号 :
NM_001901.2
UniProt数据库登录号 :
P29279
NCBI分子量 :
35,205 Da
NCBI信号通路 :
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); PPARA Activates Gene Expression Pathway (530749); Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway (119544); TGF-beta Receptor Signaling Pathway (138024)
NCBI总结 :
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
UniProt数据库总结 :
CTGF: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Belongs to the CCN family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Cell adhesion; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 6q23.1. Cellular Component: Golgi apparatus; proteinaceous extracellular matrix; extracellular space; cis-Golgi network; intracellular membrane-bound organelle; perinuclear region of cytoplasm; extracellular region; plasma membrane; cell cortex; cytosol. Molecular Function: heparin binding; integrin binding; insulin-like growth factor binding; protein binding; growth factor activity; fibronectin binding. Biological Process: response to peptide hormone stimulus; epidermis development; response to anoxia; cell-matrix adhesion; positive regulation of collagen biosynthetic process; positive regulation of JNK cascade; positive regulation of caspase activity; cellular lipid metabolic process; response to estradiol stimulus; cell-cell signaling; positive regulation of cell proliferation; positive regulation of stress fiber formation; tissue homeostasis; response to glucose stimulus; response to wounding; regulation of cell growth; angiogenesis; cell adhesion; cell differentiation; positive regulation of cell activation; cartilage condensation; integrin-mediated signaling pathway; transcription initiation from RNA polymerase II promoter; cell migration; ossification; fibroblast growth factor receptor signaling pathway; organ senescence; response to mineralocorticoid stimulus; response to amino acid stimulus; gene expression; regulation of chondrocyte differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of cell differentiation; lung development
尺寸1 :
0.1毫克
价格1 :
540美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。