抗体

兔抗人类CXCL9

MBS223923

0.1毫克

540美元

多克隆

兔

未共轭

免疫印迹, 酶联免疫吸附测定, 酶免疫法

抗体

兔抗人类CXCL9

CXCL9

C-X-C motif chemokine 9; C-X-C motif chemokine 9; C-X-C motif chemokine 9; gamma-interferon-induced monokine; monokine induced by gamma interferon; monokine induced by interferon-gamma; small-inducible cytokine B9; chemokine (C-X-C motif) ligand 9; Gamma-interferon-induced monokine; Monokine induced by interferon-gamma; HuMIG; MIG; Small-inducible cytokine B9

CXCL9

CXCL9; CXCL9; CMK; MIG; Humig; SCYB9; crg-10; CMK; MIG; SCYB9; HuMIG; MIG

CXCL9_HUMAN

多克隆

IgG

兔

125

Purified. Purified IgG - lyophilised

IgG concentration 1.0mg/ml after reconstitution

Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of reconstitution.

ELISA (EIA), Functional Assays (FN), Immunohistology Paraffin, Western Blot (WB)

ELISA: Minimum Dilution: 0.5; Maximum Dilution: 2.0ug/ml;. Functional Assays: Minimum Dilution: 5.0; Maximum Dilution: 7.0ug/ml;. Immunohistology - Paraffin. Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. . Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml

Reconstitution: Reconstitute with 0.1ml distilled water Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For long term storage the addition of 0.09% sodium azide is recommended.

Immunogen: Recombinant human CXCL9. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antiserum to human CXCL9 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. Target Species: Human

Rabbit anti Human CXCL9 polyclonal antinbody recognizes human CXCL9, otherwise known as MIG (monokine induced by Interferon-gamma), a member of the CXC family of chemokine receptors, secreted by interferon stimulated monocytes, macrophages (Muller et al. 2010) and endothelial cells (Loos et al. 2006) CXCL9 signals through binding to CD183 (CXCR3). CXCL9 acts as a Th1 (type 1 helper T) cell chemoattractant, and plays a role in the growth, activation and movement of cells associated with immune and inflammatory responses, and in tumour growth inhibition and angiogenesis (Whiting et al. 2004). Studies have shown that CXCL9 is active against E Coli, S.aureus, L.monocytogenes (Cole et al. 2001) and S.pyogenes (Egesten et al. 2007).

4505187

NP_002407.1

NM_002416.2

Q07325

14,019 Da

CXCR3-mediated Signaling Events Pathway (138011); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (i) Signalling Events Pathway (119550)

This antimicrobial gene encodes a protein thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Sep 2014]

CXCL9: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family. Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 4q21. Cellular Component: extracellular space; extracellular region; external side of plasma membrane. Molecular Function: protein binding; CXCR3 chemokine receptor binding; chemokine activity; cytokine activity. Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; cellular defense response; defense response; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; immune response; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of cAMP metabolic process; chemotaxis; inflammatory response; signal transduction; defense response to virus; positive regulation of myoblast differentiation; regulation of cell proliferation

0.1毫克

540美元