蛋白

重组人类白细胞介素-10

MBS232252

0.01毫克

440美元

重组蛋白

重组人类白细胞介素-10

IL-10

interleukin-10; Interleukin-10; interleukin-10; T-cell growth inhibitory factor; cytokine synthesis inhibitory factor; interleukin 10; Cytokine synthesis inhibitory factor; CSIF

白细胞介素10;白细胞介素10;CSIF;TGIF;GVHDS;IL-10;IL10A;IL-10;CSIF

IL10_HUMAN

178

>98% by SDS PAGE and HPLC analysis

Purified recombinant IL-10 - lyophilised

Total protein concentration 0.1mg/ml after reconstitution.

Prior to reconstitution store at 4 degree C. Following reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 3 months from date of reconstitution.

ELISA (EIA), Functional Assays (FN), Western Blot (WB)

ELISA: Minimum Dilution: 0.2; Maximum Dilution: 0.4ng/well;. Functional Assays: Minimum Dilution: 0.2; Maximum Dilution: 20ng/ml;. Western Blotting: Minimum Dilution: 1.5; Maximum Dilution: 3.0ng/lane

Reconstitution: Reconstitute with 0.1ml of 5mM sodium phosphate pH 7.2. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.After the initial reconstitution step, the product should be diluted to a working concentration using an aqueous buffer containing 0.1% BSA (or any albumin), or diluted in culture media containing serum such as FCS. Preparation: Recombinant protein expressed in Escherichia coli

Buffer Solution: Sodium Phosphate. Activity: 5 x 105 units/mg. Target Species: Human

MBS232252 is a 161 amino acid recombinant IL-10 cytokine, with a range of reported properties including inhibition of macrophage mediated cytokine synthesis, suppression of the delayed type hypersensitivity response, and stimulation of the Th2 cells response. Recombinant human IL-10 has an ED50 of

10835141

NP_000563.1

NM_000572.2

P22301

Protein Molecular Weight: 18.6 kD

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The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]

0.01毫克

440美元